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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A multiple microwave ablation strategy in patients with initially unresectable colorectal cancer liver metastases - A safety and feasibility study of a new concept
European Journal of Surgical Oncology, Volume 40, No. 11, Year 2014
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Description
Aims: Resection for colorectal cancer liver metastases is indicated when an R0 resection with preservation of a sufficient future liver remnant (FLR) is achievable. Multimodality conversion of initially unresectable patients to resectable is possible in some patients. We present results of a downstaging strategy using microwave ablation (MWA). Patients and methods: In patients where resection was precluded by absence of a tumour-free FLR due to the extent of segmental tumour engagement, but with the potential to clear the whole liver with multiple local ablations, MWA was performed at laparotomy using ultrasound guidance or computer-assisted navigation. Mortality and morbidity was recorded and the overall and disease-free survival of the ablated patients was compared to data of two historic cohorts. Results: Ten of twenty treated patients were alive at median follow-up 25 months. There was no perioperative mortality, with MWAassociated complications being mild to moderate. The MWA group showed a 4-year overall survival of 41%, compared to 70% for a historic cohort of primarily resected patients and 4% for patients with palliative treatment. Conclusion: Results of the multiple ablation strategy in the defined population suggest a survival benefit, compared to palliative chemotherapy alone with acceptable associated morbidity and no perioperative mortality. © 2014 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Engstrand, Jennie
Sweden, Stockholm
Karolinska Institutet
Nilsson, Henrik
Sweden, Stockholm
Karolinska Institutet
Jansson, Anders
Sweden, Stockholm
Karolinska Universitetssjukhuset
Isaksson, Bengt
Sweden, Stockholm
Karolinska Universitetssjukhuset
Freedman, Jacob
Sweden, Stockholm
Karolinska Institutet
Lundell, Lars Ragnar
Sweden, Stockholm
Karolinska Universitetssjukhuset
Jonas, Eduard G.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 34
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejso.2014.05.003
ISSN:
07487983
Research Areas
Cancer
Study Design
Cross Sectional Study
Cohort Study