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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Effect of praziquantel on the immature stages of Schistosoma haematobium
International Journal for Parasitology, Volume 35, No. 13, Year 2005
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Description
Schistosoma mansoni is known to be refractory to praziquantel treatment in the pre-patent period of infection. Since Schistosoma haematobium has a much longer pre-patent period (10-12 weeks vs. 5-6 for the former species), we asked the question whether a correspondingly longer period of insusceptibility exists in urinary schistosomiasis. In hamsters treated at different times after infection, S. haematobium was partially refractory to praziquantel when treatment was given at week 5, but showed practically full sensitivity at 7-8 weeks and later times. Schistosoma haematobium worms obtained at different times after infection and exposed in vitro to praziquantel were refractory to low drug concentrations between 4 and 6 weeks, but were clearly affected at higher concentrations and at later time points. We conclude that S. haematobium does not have a praziquantel-insensitive window longer than in S. manson, in spite of its much longer maturation period. In addition, refractoriness of immature stages can be overcome at higher drug concentrations. © 2005 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Botros, Sanaa
Egypt, Giza
Theodor Bilharz Research Institute
Pica-Mattoccia, Livia
Italy, Rome
Consiglio Nazionale Delle Ricerche
William, Samia
Egypt, Giza
Theodor Bilharz Research Institute
El-Lakkany, N. M.
Egypt, Giza
Theodor Bilharz Research Institute
Cioli, Donato
Italy, Rome
Consiglio Nazionale Delle Ricerche
Statistics
Citations: 53
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.ijpara.2005.05.002
ISSN:
00207519
Research Areas
Infectious Diseases