Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vitro infection of human macrophages with human T-cell leukemia virus type 1
Blood, Volume 81, No. 6, Year 1993
Notification
URL copied to clipboard!
Description
The tropism of the human T-cell leukemia virus type 1 (HTLV-1) for the cells of monocyte-macrophage lineage was evaluated by the coculture of blood monocyte-derived macrophages, with irradiated cells of HTLV-1 producing cell lines MT2 or C91/PL. The susceptibility to HTLV-1 was assessed by the detection of viral DNA using the polymerase chain reaction method. HTLV-1 gene expression in the cells was detected using in situ hybridization and by immunofluorescent staining of viral antigen. The presence of type C virus-like particles detected by electron microscopy and the ability to infect normal cord blood lymphocytes demon-strated that the infected macrophages produced infectious virus. These results indicate that human macrophages are susceptible in vitro to productive HTLV-1 infection, and thus might be involved in the pathogenesis of HTLV-1-related diseases. © 1993 by The American Society of Hematology.
Authors & Co-Authors
de Revel, Thierry
France, Fontenay-aux-roses
Cea Fontenay Aux Roses
Mabondzo, Aloïse M.
Unknown Affiliation
Roques, Pierre A.
Unknown Affiliation
Neveux, Yves
Unknown Affiliation
Bahuau, Michel
Unknown Affiliation
Fleury, Hervè J.A.
Unknown Affiliation
Dormont, Dominique
Unknown Affiliation
Statistics
Citations: 29
Authors: 7
Affiliations: 1
Identifiers
ISSN:
00064971
Research Areas
Genetics And Genomics