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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus
Archives of Virology, Volume 158, No. 8, Year 2013
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Description
This study aimed at investigating the effect of progesterone on interferon signaling pathways in peripheral blood mononuclear cells (PBMCs) of patients infected with hepatitis C virus (HCV). PBMCs were isolated from peripheral blood of 38 treatment-naïve HCV-infected patients, pooled, and stimulated with progesterone in the presence and absence of its receptor antagonist, mifepristone, along with interferon alpha (IFN-α) or imiquimod. Toll-like receptor (TLR) 7 and myxovirus resistance protein A (MxA) were quantified in PBMCs using RT-qPCR. Imiquimod alone or combined with progesterone did not change MxA expression in HCV-infected PBMCs. Progesterone decreased the inducing effect of IFN-α on TLR-7 expression in both males and females. Moreover, progesterone stimulation prior to IFN-α treatment attenuated the Jak/STAT pathway, which was reflected by decreased expression of MxA in females. Progesterone showed a negative impact on the IFN signaling pathway in HCV-infected PBMCs as it decreased the expression of TLR-7 in both genders, while MxA expression was decreased only in females. © 2013 Springer-Verlag Wien.
Authors & Co-Authors
Tayel, Sara S.
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Helmy, Amal A.
Egypt, Cairo
Faculty of Medicine
Ahmed, Rasha
Egypt, Cairo
Faculty of Medicine
Esmat, Gamal
Egypt, Cairo
Faculty of Medicine
Hamdi, Nabila
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Abdelaziz, Ahmed Ihab
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Statistics
Citations: 19
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1007/s00705-013-1673-z
ISSN:
03048608
Research Areas
Infectious Diseases
Participants Gender
Female