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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors
Movement Disorders, Volume 35, No. 10, Year 2020
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Description
Objectives: The effect of environmental and lifestyle factors on patients with LRRK2 (leucine-rich repeat kinase 2) p.Gly2019Ser (LRRK2+/PD+) compared to idiopathic PD (iPD) has yet to be thoroughly investigated. Methods: In a homogeneous Tunisian Arab Berber population, we recruited 200 idiopathic PD and 199 LRRK2 p.Gly2019Ser mutation carriers, of whom 142 had PD (LRRK2+/PD+) and 57 were unaffected (LRRK2+/PD−). Case report form (CRF) questionnaires (motor and non-motor symptoms) including the Geoparkinson Questionnaire were used to assess environmental and lifestyle factors. Results: In LRRK2+/PD+, tobacco use was significantly associated with a later median age at onset (AAO). The median AAO was 60 years (interquartile range = 52–67.25) for tobacco users, compared to 52 years (interquartile range = 45.25–61) for non-users (P = 0.0042 at adjusted α = 0.025). Additionally, we observed an independent but additive effect of black tea consumption and tobacco use. Conclusions: Our data suggest that tobacco and black tea have a protective effect on age at onset in LRRK2+/PD+. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors & Co-Authors
Lüth, Theresa
Germany, Lubeck
Universität zu Lübeck
König, I. R.
Germany, Lubeck
Universität zu Lübeck
Grünewald, Anne
Germany, Lubeck
Universität zu Lübeck
Luxembourg, Esch-sur-alzette
University of Luxembourg
Kasten, Meike
Germany, Lubeck
Universität zu Lübeck
Klein, Christine
Germany, Lubeck
Universität zu Lübeck
Hentati, F. F.
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Farrer, Matthew J.
United States, Gainesville
University of Florida
Trinh, Joanne
Germany, Lubeck
Universität zu Lübeck
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1002/mds.28238
ISSN:
08853185
e-ISSN:
15318257
Research Areas
Cancer
Substance Abuse
Study Design
Cross Sectional Study