Introduction: Cervical cancer is the third most common cancer among women worldwide, with about 500,000 new patients diagnosed and over 250,000 deaths every year. Cervical cancer screening offers protective benefits and is associated with a reduction in the incidence of invasive cervical cancer and cervical cancer mortality. But there is very low participation rate in screening for cervical cancer among low and middle-income countries. Objective: This study aimed to determine cervical cancer screening service uptake and its associated factor among age eligible women in Mekelle zone, northern Ethiopia, 2015. Methods: A community based cross-sectional study was conducted in Mekelle zone among age eligible women from February to June 2015. Systematic sampling technique was used to select 1286 women in to the study. A pre-tested structured questionnaire was used to collect relevant data. Data was entered and cleaned using EPINFO and analyzed using SPSS version 20 software package. Bivariate and Multivariate logistic regression was performed to assess association between dependent and independent variables with 95% CI and pvalue less than 0.05 was set for association. Results: The study revealed that among 1186 age eligible women, only 235(19.8%) have been screened for cervical cancer. Age (AOR = 1.799, 95%CI = 1.182-2.739), history of multiple sexual partners (AOR = 1.635, 95%CI = 1.094-2.443), history of sexually transmitted disease (AOR = 1.635,95%CI = 1.094-2.443), HIV sero status (AOR = 5.614, 95%CI = 2.595-12.144), perceived susceptibility to cervical cancer (AOR = 2.225, 95%CI = 1.308-3.783), perceived barriers to premalignant cervical lesions screening (AOR = 2.256, 95%CI = 1.447-3.517) and knowledge on cervical cancer and screening (AOR = 2.355, 95%CI = 1.155-4.802) were significant predictors of cervical cancer screening service uptake. Conclusion: Magnitude of cervical cancer screening service uptake among age eligible women is still unacceptably low. Age of the women, history of multiple sexual partners and sexually transmitted disease, HIV sero-positivity, Knowledge, Perceived susceptibility and Perceived Barrier were important predictors of cervical cancer screening service uptake.
