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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations
HIV Medicine, Volume 15, No. 5, Year 2014
Notification
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Description
Objectives: We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Methods: A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out. Analyses were limited to antiretroviral-naïve subjects to focus on the impact of HIV disease itself. A total of 16670 subjects were included in the analysis. Multilevel linear regression models assessed associations between CD4 count/VL and each of the outcomes. Statistical tests for interactions assessed whether associations differed among age groups. Results: After adjustment for gender and ethnicity, there was evidence that lower CD4 count and higher VL were associated with lower TC, LDL-C, haemoglobin and albumin concentrations but higher triglyceride concentrations. Age modified associations between CD4 count and albumin (P<0.001) and haemoglobin (P=0.001), but not between CD4 count and HDL-C, LDL-C and TC, or VL and any outcome. Among participants aged <30, 30-50 and >50 years, a 50 cells/μL lower CD4 count correlated with a 2.4 [95% confidence interval (CI) 1.7-3.0], 3.6 (95% CI 3.2-4.0) and 5.1 (95% CI 4.0-6.1) g/L lower haemoglobin concentration and a 0.09 (95% CI 0.07-0.11), 0.12 (95% CI 0.11-0.13) and 0.16 (95% CI 0.13-0.19) g/L lower albumin concentration, respectively. Conclusions: We present evidence that age modifies associations between CD4 count and plasma albumin and haemoglobin levels. A given reduction in CD4 count was associated with a greater reduction in haemoglobin and albumin concentrations among older people living with HIV. These findings increase our understanding of how the metabolic impact of HIV is influenced by age. © 2013 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.
Authors & Co-Authors
Samuel, Miriam
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Jose, Sophie
United Kingdom, London
University College London
Johnson, Ma
United Kingdom, London
Royal Free London Nhs Foundation Trust
Chadwick, David Robert
United Kingdom, Middlesbrough
South Tees Hospitals Nhs Foundation Trust
Fisher, Martin J.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Leen, Clifford L.S.
United Kingdom, Edinburgh
Western General Hospital
United Kingdom, Edinburgh
Nhs Lothian
Gompels, Mark M.
United Kingdom, Bristol
North Bristol Nhs Trust
Post, Frank A.
United Kingdom, London
King's College Hospital
Hay, Phillip E.
United Kingdom, London
St George's University Hospitals Nhs Foundation Trust
Sabin, Caroline Anne
United Kingdom, London
University College London
Ainsworth, Jonathan
Unknown Affiliation
Anderson, Jane
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Babiker, Abdel G.A.G.
Unknown Affiliation
Delpech, Valerie
Unknown Affiliation
Fisher, Martin
Unknown Affiliation
Gazzard, Brian George L.
Unknown Affiliation
Gilson, Richard John Cary
Unknown Affiliation
Gompels, Mark
Unknown Affiliation
Johnson, Margaret A.
Unknown Affiliation
Kegg, Stephen
Unknown Affiliation
Orkin, Chloe
Unknown Affiliation
Palfreeman, Adrian J.
Unknown Affiliation
Morris, Lynn G.
Unknown Affiliation
Sachikonye, Memory
Unknown Affiliation
Schwenk, Achim
Unknown Affiliation
Walsh, John Christopher
Unknown Affiliation
Hill, Teresa
United Kingdom, London
University College London
Huntington, Susie E.
United Kingdom, London
University College London
Phillips, Andrew N.
United Kingdom, London
University College London
Sabin, Caroline A.
United Kingdom, London
University College London
Thornton, Alicia Claire
United Kingdom, London
University College London
Dunn, David T.
United Kingdom, London
Medical Research Council
Glabay, Adam J.
United Kingdom, London
Medical Research Council
Orkin, Chloë M.
United Kingdom, London
Barts Health Nhs Trust
Garrett, Nigel J.
United Kingdom, London
Barts Health Nhs Trust
Lynch, Janet
United Kingdom, London
Barts Health Nhs Trust
Hand, James
United Kingdom, London
Barts Health Nhs Trust
de Souza, Carl B.S.S.
United Kingdom, London
Barts Health Nhs Trust
Fisher, Martin J.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Perry, Nicky
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Tilbury, Stuart
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Churchill, Duncan R.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Gazzard, Bg S.
United Kingdom, London
Chelsea and Westminster Hospital
Nelson, Mark Richard
United Kingdom, London
Chelsea and Westminster Hospital
Waxman, Matthew
United Kingdom, London
Chelsea and Westminster Hospital
Asboe, David
United Kingdom, London
Chelsea and Westminster Hospital
Mandalia, Sundhiya
United Kingdom, London
Chelsea and Westminster Hospital
Delpech, Valerie C.
United Kingdom, London
Public Health England
Munshi, Sajid
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Korat, Hardik
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Taylor, Christopher B.
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Gleisner, Zachary
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Campbell, Lucy J.
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Gilson, Richard
United Kingdom, London
University College London
Brima, Nataliya
United Kingdom, London
University College London
Williams, Ian G.
United Kingdom, London
University College London
Schwenk, Achim
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Ainsworth, Jonathan G.
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Wood, Christopher W.
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Miller, Sheila
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Johnson, Margaret A.
United Kingdom, London
Ucl Medical School
Youle, Mike S.
United Kingdom, London
Ucl Medical School
Lampe, Fiona C.
United Kingdom, London
Ucl Medical School
Smith, Colette Joanne
United Kingdom, London
Ucl Medical School
Grabowska, Helen
United Kingdom, London
Ucl Medical School
Chaloner, Clinton
United Kingdom, London
Ucl Medical School
Puradiredja, Dewi Ismajani
United Kingdom, London
Ucl Medical School
Walsh, John Frank
United Kingdom, London
St Mary's Hospital
Weber, Jonathan N.
United Kingdom, London
St Mary's Hospital
Ramzan, Farhan
United Kingdom, London
St Mary's Hospital
Mackie, Nicky
United Kingdom, London
St Mary's Hospital
Winston, Alan
United Kingdom, London
St Mary's Hospital
Wilson, Alan C.
United Kingdom, Edinburgh
Nhs Lothian
Allan, Sris P.
United Kingdom, Bristol
North Bristol Nhs Trust
Palfreeman, Adrian J.
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Martin, Fabiola
United Kingdom, York
York Teaching Hospital Nhs Foundation Trust
Dhillon, Mandip
United Kingdom, London
St George's University Hospitals Nhs Foundation Trust
Statistics
Citations: 12
Authors: 77
Affiliations: 23
Identifiers
Doi:
10.1111/hiv.12103
ISSN:
14642662
Research Areas
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cohort Study