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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A role for a new herpes virus (KSHV) in different forms of kaposi's sarcoma
Nature Medicine, Volume 1, No. 7, Year 1995
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Description
Kaposi's sarcoma (KS) is a previously rare, tumour-like lesion of controversial biological nature' s. KS has since the early 1980s become frequent in patients with AIDS, particularly in homosexuals KS is also endemic in Central Africa predominantly in otherwise healthy men but also in women and children’s Recently, evidence for the presence of novel, herpes virus DNA sequences in more than 90% of AIDS Kaposi lesions (AKS) was presented. This DNA was identified using representational difference analysis (RDA) generating short, unique sequences with variable homology to several herpes virus, but no intact virus was recovered. If these DNA-sequences are also present in other, non-HIV-associated forms of Kaposi's sarcoma this would strongly suggest a specific, aetiopathological involvement of this putative new herpes virus in the pathogenesis of Kaposi's sarcoma, rather than a contamination of yet another opportunistic virus in immunosuppressed AIDS patients. © 1995 Nature Publishing Group.
Authors & Co-Authors
Schalling, Martin
Sweden, Stockholm
Karolinska Institutet
Ekman, Marianne
Sweden, Stockholm
Karolinska Institutet
Kaaya, Ephata E.
Sweden, Stockholm
Karolinska Institutet
Lindé, Annika
Sweden, Solna
Public Health Agency of Sweden
Biberfeld, Peter J.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 292
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1038/nm0795-707
ISSN:
10788956
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Participants Gender
Male
Female