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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso
Genes and Immunity, Volume 6, No. 6, Year 2005
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Description
We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falciparum endemic area and we found 17 polymorphisms. In a longitudinal study, we investigated whether the 11 most frequent and informative polymorphisms were associated with mild malaria attack and maximum parasitemia, which was the highest parasitemia in each individual over 2 years. Mild malaria attack and maximum parasitemia were positively correlated. Transmission disequilibrium tests showed nominal evidence for association between TNF-1031, TNF-308, TNF851 and TNF1304 polymorphisms, and mild malaria attack on the one hand, and between TNF-238, TNF851 and TNF1304 polymorphisms, and maximum parasitemia on the other hand. After accounting for multiple tests, we confirmed the association of TNF-238 with maximum parasitemia and the association of TNF1304 and TNF851 with maximum parasitemia and mild malaria attack. The association tests with mild malaria attack suggest a moderate effect of TNF-308 polymorphism. In conclusion, our study suggests that several TNF variants may be part of the genetic determinants for maximum parasitemia and/or mild malaria attack. © 2005 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Flori, Laurence
France, Marseille
Aix Marseille Université
Delahaye, Nicolas Frédéric
France, Marseille
Aix Marseille Université
Iraqi, Fuad A.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Hernandez-Valladares, Maria
Kenya, Nairobi
International Livestock Research Institute Nairobi
Fumoux, François
France, Marseille
Aix Marseille Université
Rihet, Pascal
France, Marseille
Aix Marseille Université
Statistics
Citations: 67
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1038/sj.gene.6364231
ISSN:
14664879
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Burkina Faso