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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Diagnosis of rifampicin-resistant tuberculosis: Discordant results by diagnostic methods
African Journal of Laboratory Medicine, Volume 7, No. 2, Article 806, Year 2018
Notification
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Description
The performance of the Xpert© MTB/RIF and MTBDRplus assays for the detection of rifampicin resistant Mycobacterium tuberculosis was compared to culture-based drug susceptibility testing in 30 specimens with rifampicin-resistant and rifampicin-indeterminate Xpert MTB/RIF results collected between March 2012 and March 2014. Xpert MTB/RIF and MTBDRplus were 100% sensitive and 100% concordant for rifampicin resistance detection, but 3 of 13 samples (23%) positive for rifampicin resistance on Xpert MTB/RIF and MTBDRplus were negative for rifampicin resistance on mycobacteria growth indicator tube drug susceptibility testing. Specificity was 72% for Xpert MTB/RIF and 80% for MTBDRplus. Positive predictive value for Xpert MTB/RIF for multidrug resistant tuberculosis was 47.8% for new patients and 77.8% for previously treated patients; negative predictive value was 100% for both new and previously treated patients. The discordant rifampicin resistance test results indicate a need to fully characterise circulating rifampicin resistant Mycobacterium tuberculosis strains in Zambia and to inform the development of guidelines for decision-making in relation to diagnosis of drug-resistant tuberculosis.
Authors & Co-Authors
Mwanza, Winnie C.
Unknown Affiliation
Milimo, Deborah
Unknown Affiliation
Chilufya, Maureen M.
Unknown Affiliation
Kasese, Nkatya
Unknown Affiliation
Lengwe, Maina C.
Unknown Affiliation
Munkondya, Stembiso
Unknown Affiliation
de Haas, Petra E.W.
Unknown Affiliation
Ayles, Helen Mary
Unknown Affiliation
Muyoyeta, Monde
Unknown Affiliation
Statistics
Citations: 9
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.4102/ajlm.v7i2.806
ISSN:
22252002
Study Locations
Zambia