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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Interleukin-17A and -17F genes polymorphisms in lung cancer
Cytokine, Volume 66, No. 1, Year 2014
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Description
Interleukin-17 (IL-17) is a proinflammatory cytokines produced by T helper 17 (Th17) cells, which plays an important role in both innate and adaptive immune systems. Genetic variants in the IL-17 genes may influence the immunopathogenesis of many cancers. In our study, we investigated the association of three single-nucleotide polymorphisms (SNPs: -152 G/A, 7488 A/G and 7383 A/G) in the IL-17A and IL-17F genes with lung cancer risk, in the Tunisian population. The genotypic and allelic distributions of IL-17A and IL-17F genes polymorphisms were analyzed by Polymerase Chain-Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) for 239 patients and 258 healthy controls. Our results revealed a statistically significant association between IL-17F 7488G allele and increased lung cancer risk (P= 0.028). Stratification analysis indicated that IL-17F 7488G allele enhances the risk of lung cancer development among men and oldest age subject groups (P<. 0.05). Patients with IL-17F 7488G allele were also more likely to be diagnosed at advanced stage (P= 0.04), or with metastatic lung cancer (P= 0.035). Furthermore, no significant association between IL-17F 7383 A/G, IL-17 -152G/A polymorphisms and lung cancer risk was observed (P> 0.05). However, we reported contradictory findings on the association of IL-17 -152 G/A polymorphisms with lung cancer risk. In addition, we suggested the existence of a biological interaction between IL-17A, but not IL-17F polymorphisms and smoking. Our findings suggest that IL-17F 7488G allele is associated with increased lung cancer risk in the Tunisian population. © 2013 Elsevier Ltd.
Authors & Co-Authors
Kaabachi, Wajih
Tunisia, Tunis
Faculté de Médecine de Tunis
Tunisia, Ariana
Université de Tunis el Manar, Hôpital Abderrahmène Mami
Amor, Amira Ben
Tunisia, Tunis
Faculté de Médecine de Tunis
Tunisia, Ariana
Université de Tunis el Manar, Hôpital Abderrahmène Mami
Kaabachi, Safa
Tunisia, Tunis
Faculté de Médecine de Tunis
Tunisia, Ariana
Université de Tunis el Manar, Hôpital Abderrahmène Mami
Rafrafi, Ahlem
Tunisia, Tunis
Faculté de Médecine de Tunis
Tunisia, Ariana
Université de Tunis el Manar, Hôpital Abderrahmène Mami
Tizaoui, Kalthoum
Tunisia, Tunis
Faculté de Médecine de Tunis
Tunisia, Ariana
Université de Tunis el Manar, Hôpital Abderrahmène Mami
Hamzaoui, Kamel
Tunisia, Tunis
Faculté de Médecine de Tunis
Tunisia, Ariana
Université de Tunis el Manar, Hôpital Abderrahmène Mami
Statistics
Citations: 49
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.cyto.2013.12.012
ISSN:
10434666
e-ISSN:
10960023
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Participants Gender
Male