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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
CD8
+
T-cell responses to different HIV proteins have discordant associations with viral load
Nature Medicine, Volume 13, No. 1, Year 2007
Notification
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Description
Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely empirical. To define the relationship, at the population level, between the specificity of the cellular immune response and viral control for a relevant human pathogen, we performed a comprehensive analysis of the 160 dominant CD8+ T-cell responses in 578 untreated HIV-infected individuals from KwaZulu-Natal, South Africa. Of the HIV proteins targeted, only Gag-specific responses were associated with lowering viremia. Env-specific and Accessory/Regulatory protein-specific responses were associated with higher viremia. Increasing breadth of Gag-specific responses was associated with decreasing viremia and increasing Env breadth with increasing viremia. Association of the specific CD8+ T-cell response with low viremia was independent of HLA type and unrelated to epitope sequence conservation. These population-based data, suggesting the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection, are of relevance to HIV vaccine design and evaluation. © 2007 Nature Publishing Group.
Authors & Co-Authors
Kiepiela, Photini
South Africa, Durban
University of Kwazulu-natal
Ngumbela, Kholiswa C.
South Africa, Durban
University of Kwazulu-natal
Thobakgale, Christina F.
South Africa, Durban
University of Kwazulu-natal
Ramduth, Danni
South Africa, Durban
University of Kwazulu-natal
Honeyborne, Isobella
United Kingdom, Oxford
Nuffield Department of Medicine
Moodley, Eshia S.
South Africa, Durban
University of Kwazulu-natal
Reddy, Shabashini
South Africa, Durban
University of Kwazulu-natal
de Pierres, Chantal
South Africa, Durban
University of Kwazulu-natal
Mncube, Zenele
South Africa, Durban
University of Kwazulu-natal
Mkhwanazi, Nompumelelo Prudence
South Africa, Durban
University of Kwazulu-natal
Bishop, Karen S.
South Africa, Durban
University of Kwazulu-natal
van der Stok, Mary
South Africa, Durban
University of Kwazulu-natal
Nair, Kriebashnie S.
South Africa, Durban
University of Kwazulu-natal
Khan, Nasreen
South Africa, Durban
University of Kwazulu-natal
Crawford, Hayley
United Kingdom, Oxford
Nuffield Department of Medicine
Payne, Rebecca P.
United Kingdom, Oxford
Nuffield Department of Medicine
Leslie, Alasdair J.
United Kingdom, Oxford
Nuffield Department of Medicine
Prado, Julia Garcia
United Kingdom, Oxford
Nuffield Department of Medicine
Prendergast, Andrew J.
United Kingdom, Oxford
Nuffield Department of Medicine
Frater, John
United Kingdom, Oxford
Nuffield Department of Medicine
McCarthy, Noel Denis
United Kingdom, Oxford
University of Oxford
Brander, Christian
United States, Boston
Massachusetts General Hospital
Learn, Gerald H.
United States, Seattle
University of Washington School of Medicine
Nickle, David C.
United States, Seattle
University of Washington School of Medicine
Rousseau, Christine M.
United States, Seattle
University of Washington School of Medicine
Coovadia, Hoosen Mahomed
South Africa, Durban
University of Kwazulu-natal
Mullins, James I.
United States, Seattle
University of Washington School of Medicine
Heckerman, David E.
United States, Redmond
Microsoft Research
Walker, Bruce D.
South Africa, Durban
University of Kwazulu-natal
United States, Boston
Massachusetts General Hospital
United States, Chevy Chase
Howard Hughes Medical Institute
Goulder, Philip Jeremy Renshaw
South Africa, Durban
University of Kwazulu-natal
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 1,103
Authors: 30
Affiliations: 7
Identifiers
Doi:
10.1038/nm1520
ISSN:
10788956
e-ISSN:
1546170X
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
South Africa