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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica
Peptides, Volume 29, No. 9, Year 2008
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Description
Temporins are small antimicrobial peptides isolated from North American and Eurasian ranid frogs that are particularly active against Gram-positive bacteria. To date, no temporins have been characterized from North African frog species. We isolated three novel members of the temporin family, named temporin-1Sa (FLSGIVGMLGKLFamide), -1Sb (FLPIVTNLLSGLLamide), and -1Sc (FLSHIAGFLSNLFamide), from the skin of the Sahara frog Pelophylax (Rana) saharica originating from Tunisia. These temporins were identified by a combined mass spectrometry/molecular cloning approach. Temporin-1Sa was found to be highly active against Gram-positive and Gram-negative bacteria, yeasts and fungi (MIC = 2-30 μM). To our knowledge, this is the first 13-residue member of the temporin family with a net charge of +2 that shows such broad-spectrum activity with particularly high potency on the clinically relevant Gram-negative strains, Escherichia coli (MIC = 10 μM) and Pseudomonas aeruginosa (MIC = 31 μM). Moreover, temporin-1Sa displays significant antiparasitic activity (IC50 ∼ 20 μM) against the promastigote and amastigote stages of Leishmania infantum. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Abbassi, Feten
France, Paris
Sorbonne Université
Tunisia, Sousse
Faculty of Medicine Sousse
Oury, Bruno
France, Montpellier
Ird Centre de Montpellier
Blasco, Thierry
France, Paris
Sorbonne Université
Sereno, Denis
France, Montpellier
Ird Centre de Montpellier
Bolbach, Gérard
France, Paris
Sorbonne Université
Nicolas, Pierre
France, Paris
Sorbonne Université
Hani, Khaled
Tunisia, Sousse
Faculty of Medicine Sousse
Amiche, Mohamed
France, Paris
Sorbonne Université
Ladram, Ali
France, Paris
Sorbonne Université
Statistics
Citations: 73
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.peptides.2008.05.008
ISSN:
01969781
Study Locations
Tunisia