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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Experience with Radical Resection in the Management of Proximal Bile Duct Cancer
HPB Surgery, Volume 1, No. 4, Year 1989
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Description
Multiple surgical and nonsurgical approaches have been advocated for the treatment of proximal bile duct cancer. However, survival appears longest when a resection can be performed. Fifteen patients treated at a university center were managed with an aggressive surgical approach. Resection of the tumor was performed in 13 of 15 patients (87%). Of the patients undergoing resection, major hepatic resection was performed in 8 (62%), while excision of vessels with reconstruction was performed in 5 (38%). Eleven of the 13 resected patients (85%) were discharged from the hospital. Clinical symptoms of recurrent disease occurred between 3 and 36 months after surgery in 7 patients, 6 of whom have died. Three other patients are alive at 5, 21, and 36 months without clinical evidence of recurrence. There was no correlation between the completeness of resection and the duration of disease-free survival. These results demonstrate that radical resection of high bile duct tumors can be accomplished with an acceptable early mortality rate, thereby extending the benefits of resection to a higher proportion of patients. While resection is clearly effective at controlling local disease and providing palliation of jaundice, surgical cure remains exceptional. Further improvement in the therapy of bile duct cancer must await development of more effective multi-modality approaches. © 1989, Harwood Academic Publishers GmbH.
Authors & Co-Authors
Emond, Jean Crawford
United States, Chicago
Pritzker School of Medicine
Mayes, James T.
United States, Chicago
Pritzker School of Medicine
Rouch, Dale A.
United States, Chicago
Pritzker School of Medicine
Richard Thistlethwaite, J.
United States, Chicago
Pritzker School of Medicine
Broelsch, Christopher Erich
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 6
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1155/1989/37642
ISSN:
08948569
e-ISSN:
16078462
Research Areas
Cancer
Health System And Policy