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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Candida infective endocarditis: An observational cohort study with a focus on therapy
Antimicrobial Agents and Chemotherapy, Volume 59, No. 4, Year 2015
Notification
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Description
Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis. Copyright © 2015, American Society for Microbiology.
Authors & Co-Authors
Arnold, Christopher J.
United States, Durham
Duke University
Johnson, Melissa D.
United States, Durham
Duke University
Bayer, Arnold S.
United States, Los Angeles
University of California, Los Angeles
Bradley, Suzanne F.
United States, Ann Arbor
Va Ann Arbor Healthcare System
Giannitsioti, Efthymia
Greece, Athens
Athens General Hospital
Miró, José María
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Tornos, Pilar
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Tattevin, Pierre
France, Rennes
Pontchaillou University
Strahilevitz, Jacob
Israel, Jerusalem
Hebrew University of Jerusalem
Israel, Tel Aviv-yafo
Tel Aviv University
Spelman, Denis W.
Australia, Melbourne
The Alfred
Athan, E.
Australia, Geelong
Barwon Health
Nacinovich, Francisco M.
Argentina, Buenos Aires
Instituto Cardiovascular de Buenos Aires
Fortes, Claudio Querido
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Lamas, C. C.
Brazil, Laranjeiras
Instituto Nacional de Cardiologia
Barŝić, Bruno U.
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Fernández-Hidalgo, Núria
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Muñoz, Patricia E.
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Chu, Vivian H.
United States, Durham
Duke University
United States
Ice Coordinating Center
Clara, Liliana O.
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Sánchez, Marisa Carmen
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Casabe´, José Horacio
Argentina, Buenos Aires
Fundacion Favaloro
Cortés, Claudia Mariana
Argentina, Buenos Aires
Fundacion Favaloro
Oses, Pablo Fernández
Argentina, Buenos Aires
Instituto Cardiovascular de Buenos Aires
Ronderos, Ricardo Ernesto
Argentina, Buenos Aires
Instituto Cardiovascular de Buenos Aires
Súcari, Adriana
Argentina, Buenos Aires
Instituto Cardiovascular de Buenos Aires
Thierer, Jorge Mario
Argentina, Buenos Aires
Instituto Cardiovascular de Buenos Aires
Altclas, Javier David
Argentina, Buenos Aires
Sanatorio de la Trinidad
Kogan, Silvia
Argentina, Buenos Aires
Sanatorio de la Trinidad
Harris, Owen C.
Australia, Geelong
Barwon Health
Kennedy, Karina J.
Australia, Canberra
Canberra Hospital
Tan, Ren
Australia, Canberra
Canberra Hospital
Gordon, David Llewellyn
Australia, Adelaide
Flinders Medical Centre
Papanicolas, Lito Electra
Australia, Adelaide
Flinders Medical Centre
Korman, Tony M.
Unknown Affiliation
Kotsanas, Despina
Unknown Affiliation
Dever, Robyn
Australia, Sydney
St George Hospital
Jones, Philip D.
Australia, Sydney
St George Hospital
Australia, Sydney
Unsw Sydney
Konecny, Pam
Australia, Sydney
St George Hospital
Lawrence, Richard H.
Australia, Sydney
St George Hospital
Rees, David M.
Australia, Sydney
St George Hospital
Ryan, Suzanne
Australia, Sydney
St George Hospital
Australia, Sydney
Unsw Sydney
Feneley, Michael P.
Unknown Affiliation
Harkness, John L.
Unknown Affiliation
Post, Jeffrey J.
Australia, Sydney
Unsw Sydney
Reinbott, Porl
Australia, Sydney
Unsw Sydney
Gattringer, Rainer
Austria, Vienna
Allgemeines Krankenhaus Wien
Wiesbauer, Franz
Austria, Vienna
Allgemeines Krankenhaus Wien
Andrade, Adriana Ribas
Brazil
Ana Neri Hospital
de Brito, Ana Cla´udia Passos
Brazil
Ana Neri Hospital
Guimarães, Armênio Costa
Brazil
Ana Neri Hospital
Grínberg, Max
Brazil, Sao Paulo
Universidade de São Paulo
Mansur, José Alfredo
Brazil, Sao Paulo
Universidade de São Paulo
Siciliano, Rinaldo Focaccia
Brazil, Sao Paulo
Universidade de São Paulo
Strabelli, Tania Mara Varejao
Brazil, Sao Paulo
Universidade de São Paulo
Vieira, Marcelo Luiz Campos
Brazil, Sao Paulo
Universidade de São Paulo
de Medeiros Tranchesi, Regina Aparecida
Brazil, Sao Paulo
Hospital 9 de Julho
Paiva, Marcelo Goulart
Brazil, Sao Paulo
Hospital 9 de Julho
Fortes, Claudio Querido
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
de Oliveira Ramos, Auristela Isabel
Brazil, Sao Paulo
Instituto Dante Pazzanese de Cardiologia
Weksler, Clara
Brazil, Laranjeiras
Instituto Nacional de Cardiologia
Ferraiuoli, Giovanna Ianini D.Almeida
Brazil, Laranjeiras
Instituto Nacional de Cardiologia
Golebiovski, Wilma Felix
Brazil, Laranjeiras
Instituto Nacional de Cardiologia
Karlowsky, James A.
Canada, Winnipeg
University of Manitoba
Keynan, Y.
Canada, Winnipeg
University of Manitoba
Morris, Andrew Mark
Canada, Winnipeg
University of Manitoba
Rubinstein, Ethan
Canada, Winnipeg
University of Manitoba
Israel, Tel Aviv-yafo
Tel Aviv University
Jones, Sandra Braun
Chile, Santiago
Pontificia Universidad Católica de Chile
García, Patricia Muñoz
Chile, Santiago
Pontificia Universidad Católica de Chile
Cereceda, Mauricio
Chile, Santiago
Hospital Clínico Universidad de Chile
Fica C, Alberto E.
Chile, Santiago
Hospital Clínico Universidad de Chile
Mella, Rodrigo Montagna
Chile, Santiago
Hospital Clínico Universidad de Chile
Fernández, Ricardo Rodríguez
Colombia
Clinica Cardiovascular Medellín
Franco-Lara, Liliana F.
Colombia
Clinica Cardiovascular Medellín
González, Javier Mauricio
Colombia
Clinica Cardiovascular Medellín
Jaramillo, Astrid Natalia Molina
Colombia
Clinica Cardiovascular Medellín
Bukovski, Suzana
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Krajinović, Vladimir
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Pangerčić, Ana
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Rudež, Igor
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Vincelj, Josip
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Freiberger, Tomas
Czech Republic, Brno
Středoevropský Technologický Institut
Pol, Jiří
Czech Republic, Brno
Centre for Cardiovascular Surgery and Transplantation
Žaloudíková, Barbora
Czech Republic, Brno
Centre for Cardiovascular Surgery and Transplantation
Ashour, Zainab
Egypt, Cairo
Faculty of Medicine
Kholy, Amani El
Egypt, Cairo
Faculty of Medicine
Mishaal, Marwa
Egypt, Cairo
Faculty of Medicine
Osama, Dina
Egypt, Cairo
Faculty of Medicine
Rizk, Hussien Hassan
Egypt, Cairo
Faculty of Medicine
Aissa, Neijla
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Alauzet, Corentine
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Alla, François F.
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Campagnac, Catherine
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Doco-Lecompte, Thanh
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Selton-Suty, Christine
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Casalta, Jean Paul
France, Marseille
Aix Marseille Université
Fournier, Pierre Édouard
France, Marseille
Aix Marseille Université
Habib, Gilbert B.
France, Marseille
Aix Marseille Université
Raoult, Didier A.
France, Marseille
Aix Marseille Université
Thuny, Franck Roland
France, Marseille
Aix Marseille Université
Delahaye, Franc¸ois
France, Lyon
Hopital Louis Pradel
Delahaye, Armelle
France, Lyon
Hopital Louis Pradel
Vandenesch, François
France, Lyon
Hopital Louis Pradel
Donal, Erwan
France, Rennes
Pontchaillou University
Donnio, Pierre Yves
France, Rennes
Pontchaillou University
Michelet, Christian
France, Rennes
Pontchaillou University
Ruşinaru, Dan M.D.
France, Bron
South Hospital Amiens
Tribouilloy, Christophe M.
France, Bron
South Hospital Amiens
Bernard, Yvette F.
France
University Medical Center of Besançon
Chirouze, Catherine
France
University Medical Center of Besançon
Hoën, Bruno
France
University Medical Center of Besançon
Leroy, Joël E.
France
University Medical Center of Besançon
Plèsiat, Patrick
France
University Medical Center of Besançon
Naber, Christoph Kurt
Germany, Bochum
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Ggmbh
Germany, Duisburg
Universität Duisburg-essen
Paniara, Olga I.
Greece, Athens
Evagelismos Hospital
Skoutelis, Athanasios Th
Greece, Athens
Evagelismos Hospital
Francis, Johnson
India, Kozhikode
Calicut Medical College
Thomas, Vinod
India, Kozhikode
Calicut Medical College
Venugopal, Krishnan
India, Kozhikode
Calicut Medical College
Hannan, Margaret M.
Ireland
Mater Hospitals
Hurley, John P.
Ireland
Mater Hospitals
Korem, Maya
Israel, Jerusalem
Hebrew University of Jerusalem
Durante-Mangoni, Emanuele
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Mattucci, Irene
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Cecchi, Enrico
Italy, Vittoria
Maria Vittoria Hospital
De Rosa, Francesco Giuseppe
Italy, Vittoria
Maria Vittoria Hospital
Forno, Davide
Italy, Vittoria
Maria Vittoria Hospital
Imazio, Massimo M.
Italy, Vittoria
Maria Vittoria Hospital
Grossi, Paolo Antonio
Italy, Varese
Azienda Ospedaliera Ospedale Di Circolo e Fondazione Macchi Di Varese
Raglio, Annibale
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Ravasio, Veronica
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Rizzi, Marco
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Suter, Fredy
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Carosi, Giaampiero
Italy, Brescia
Spedali Civili Di Brescia
Kanafani, Zeina A.
Lebanon, Beirut
American University of Beirut
Kanj, Souha S.
Lebanon, Beirut
American University of Beirut
Sharif-Yakan, Ahmad
Lebanon, Beirut
American University of Beirut
Tamin, Syahidah Syed
Malaysia
National Heart Institute
van der Meer, Jan T.M.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Chambers, S. T.
New Zealand, Dunedin
University of Otago
Holland, David James
New Zealand, Auckland
Middlemore Hospital, Auckland
Morris, Arthur James
Unknown Affiliation
Raymond, Nigel J.
New Zealand, Wellington
Wellington Hospital, new Zealand
Read, Kerry M.
New Zealand, Auckland
North Shore Hospital
Murdoch, David Roger
New Zealand, Dunedin
University of Otago
Drãgulescu, Ştefan Iosif
Romania, Bucharest
Victor Babes National Institute
Vinogradova, Tatiana L.
Unknown Affiliation
Edathodu, Jameela
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Halim, Magid Abdel
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Tan, Ru San
Singapore, Singapore City
National Heart Centre Singapore
Lejko-Zupanc, Tatjana
Slovenia, Ljubljana
Medical Center Ljublijana
Logar, Mateja
Slovenia, Ljubljana
Medical Center Ljublijana
Mueller-Premru, Manica
Slovenia, Ljubljana
Medical Center Ljublijana
Commerford, Patrick Joseph
South Africa, Cape Town
University of Cape Town
Commerford, Anita
South Africa, Cape Town
University of Cape Town
Deetlefs, Eduan
South Africa, Cape Town
University of Cape Town
Hansa, Cass
South Africa, Cape Town
University of Cape Town
Ntsekhe, Mpiko
South Africa, Cape Town
University of Cape Town
Almela, Manuel Vidal
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Armero, Yolanda
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Azqueta, Manel
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Cervera, Carlos García
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Falces, Carlos
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
García-De-La-Mària, Cristina
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Gatell, José Mariá A.
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Llopis, Jaume L.
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Marco, Francesc
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Mestres, Carlos Alberto
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Moreno, Asunciõn Pizarro
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Ninot, Salvador
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Parè, Carles
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Pericàs, Juan Manuel
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Ramírez, José Luís De Francisco
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Sitges, Marta
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Anguera, Ignasi
Spain, Sabadell
Hospital de Sabadell
Bouza, E. Santiago
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Ramallo, Víctor González
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Kestler, Martha
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Pinilla, Blanca
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Almirante, Benito
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
de Alarcón, Ari´stides
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Olaison, Lars
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Snygg-Martin, Ulrika
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Pachirat, O.
Thailand, Khon Kaen
Khon Kaen University
Casey, Anna L.
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Elliott, Thomas S.J.
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Lambert, Peter A.
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Watkin, Richard W.
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Klein, John L.
United Kingdom, London
St Thomas' Hospital
Kauffman, Carol A.
United States, Ann Arbor
Va Ann Arbor Healthcare System
Bedimo, Roger J.
United States
Va Medical Center
Corey, Gordon Ralph
United States, Durham
Duke University
United States
Ice Coordinating Center
Drew, Laura A.
United States, Durham
Duke University
Fowler, Vance G.
United States, Durham
Duke University
United States
Ice Coordinating Center
Holland, Thomas L.
United States, Durham
Duke University
Lalani, Tahaniyat N.
United States, Durham
Duke University
Mudrick, Daniel W.
United States, Durham
Duke University
Samad, Zainab
United States, Durham
Duke University
Stryjewski, Martín E.
United States, Durham
Duke University
Wang, Andrew
United States, Durham
Duke University
Woods, Christopher W.
United States, Durham
Duke University
Lerakis, Stamatios
United States, Atlanta
Emory University
Cantey, Robert
United States, Charleston
Medical University of South Carolina
Steed, Lisa L.
United States, Charleston
Medical University of South Carolina
Wray, Dannah W.
United States, Charleston
Medical University of South Carolina
Dickerman, Stuart A.
United States, New York
New York University
DiPersio, Joseph R.
United States, Akron
Summa Health System
Baddley, John W.
United States, Birmingham
The University of Alabama at Birmingham
Patel, Mukesh
United States, Birmingham
The University of Alabama at Birmingham
Peterson, Gail E.
United States, Dallas
Ut Southwestern Medical Center
Stancoven, Amy Butler
United States, Dallas
Ut Southwestern Medical Center
Levine, Donald P.
United States, Detroit
Wayne State University
Rybak, Michael Joseph
United States, Detroit
Wayne State University
Cabell, Christopher H.
United States, Durham
Iqvia Inc.
Harding, Tina M.
United States
Ice Coordinating Center
Park, Lawrence P.
United States
Ice Coordinating Center
Karchmer, Adolf W.
Unknown Affiliation
Sexton, Daniel John
Unknown Affiliation
Durack, David T.
Unknown Affiliation
Eykyn, Susannah J.
Unknown Affiliation
Moreillon, Philippe
Unknown Affiliation
Sexton, Daniel J.
Unknown Affiliation
Statistics
Citations: 61
Authors: 221
Affiliations: 81
Identifiers
Doi:
10.1128/AAC.04867-14
ISSN:
00664804
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative