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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Relationship between levels of inflammatory cytokines in the genital tract and CD4
+
cell counts in women with acute HIV-1 infection
Journal of Infectious Diseases, Volume 198, No. 5, Year 2008
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Description
Inflammatory responses at mucosal surfaces after human immunodeficiency virus type 1 (HIV-1) transmission may influence disease outcome.We evaluated levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α, IL-8, IL-10, and IL-12 in genital tract and plasma specimens from 44 women with acute HIV infection and 29 HIV-negative control women (13 of whom were women in the acute HIV infection cohort who had preinfection samples available for analysis). Women with acute HIV infection had significantly elevated levels of IL-6, IL-10, and IL-12 in genital tract specimens and elevated levels of IL-1β, IL-8, and IL-10 in plasma specimens, compared with HIV-negative control women. Levels of IL-1β, IL-6, and IL-8 in cervicovaginal specimens from women with acute HIV infection showed a significant inverse correlation with systemic CD4+ cell counts, suggesting that mucosal inflammation is associated with low CD4+ cell counts during acute HIV infection. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Bebell, Lisa M.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Passmore, Jo Ann Shelley
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Faculty of Health Sciences
Williamson, Carolyn
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
South Africa, Cape Town
University of Cape Town
Mlisana, Koleka P.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Iriogbe, Itua
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
van Loggerenberg, Francois
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Abdool Karim, Quarraisha Abdool
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Statistics
Citations: 78
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1086/590503
ISSN:
00221899
Research Areas
Cancer
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female