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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Accuracy of SD Malaria Ag P.f/Pan® as a rapid diagnostic test in French Amazonia
Malaria Journal, Volume 20, No. 1, Article 369, Year 2021
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Description
Background: French Guiana (FG) is a French overseas territory where malaria is endemic. The current incidence rate is 0.74‰ inhabitants, and Plasmodium vivax is widely predominating even though Plasmodium falciparum is still present due to imported cases mainly from Africa. In FG, rapid diagnostic test (SD Malaria Ag P.f/Pan®) is based on the detection of pan-pLDH, PfHRP2, and PfHRP3 antigens, while in South America, the share of deletion of PfHRP2 gene is significantly increasing. Accordingly, the study questions the reliability of RDTs in the Amazonian context. Methods: The study is retrospective. It is conducted over 4 years and analysed 12,880 rapid diagnostic tests (RDTs) compared to concomitant Blood Film Tests (BFTs) sampled for malaria diagnosis. Results: The global assessment of the accuracy of SD Malaria Ag P.f/Pan® in the diagnostic of malaria shows both Positive and Negative Predictive Values (PPV and NPV) higher than 95%, except for PPV in the diagnosis of malaria to P. falciparum (88%). Overall, the concordance rate between RDT and BFT (positive/positive; negative/negative) was 99.5%. The PPV of the RDT in the follow-up of patients diagnosed with P. falciparum was the lowest during the first 28 days. The PPV of the RDT in the follow-up of patients diagnosed with P. vivax was the lowest during the first 21 days. The global sensitivity of SD Malaria Ag P.f/Pan® test was, on average, 96% (88.2–100) for P. falciparum and 93% (90.6–94.2) for P. vivax. The global specificity was 99.8% (99.5–100) for all included species. Conclusion: SD Malaria Ag P.f/Pan® is a reliable rapid test used for the first-line diagnosis in remote healthcare centres. The test results should be interpreted in the light of patient’s recent medical history and the date of arrival to FG. © 2021, The Author(s).
Authors & Co-Authors
Pujo, Jean Marc
French Guiana, Cayenne
Centre Hospitalier Andree Rosemon
Blanchet, Denis
French Guiana, Cayenne
Centre Hospitalier Andree Rosemon
France, Cayenne
Université de Guyane
France, Lille
Institut Pasteur de Lille
Djossou, Félix
French Guiana, Cayenne
Centre Hospitalier Andree Rosemon
Kallel, Hatem
French Guiana, Cayenne
Centre Hospitalier Andree Rosemon
France, Cayenne
Université de Guyane
France, Lille
Institut Pasteur de Lille
Demar, Magalie Pierre
French Guiana, Cayenne
Centre Hospitalier Andree Rosemon
France, Cayenne
Université de Guyane
France, Lille
Institut Pasteur de Lille
Statistics
Citations: 2
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1186/s12936-021-03902-z
ISSN:
14752875
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cohort Study