Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa
Blood Pressure, Volume 23, No. 3, Year 2014
Notification
URL copied to clipboard!
Description
Background. Compared with Caucasians, African Americans have lower heart rate variability (HRV) in the high-frequency domain, but there are no studies in blacks born and living in Africa. Methods. In the Newer versus Older Antihypertensive agents in African Hypertensive patients trial (NCT01030458), patients (30-69 years) with uncomplicated hypertension (140-179/90-109 mmHg) were randomized to single-pill combinations of bisoprolol/hydrochlorothiazide (R) or amlodipine/valsartan (E). 72 R and 84 E patients underwent 5-min ECG recordings at randomization and 8, 16 and 24 weeks. HRV was determined by fast Fourier transform and autoregressive modelling. Results. Heart rate decreased by 9.5 beats/min in R patients with no change in E patients (- 2.2 beats/min). R patients had reduced total (- 0.13 ms; p = 0.0038) and low-frequency power (- 3.6 nu; p = 0.057), higher high-frequency (+ 3.3 nu; p = 0.050) and a reduced low- to high-frequency ratio (- 0.08; p = 0.040). With adjustment for heart rate, these differences disappeared, except for the reduced low-frequency power in the R group (- 4.67 nu; p = 0.02). Analyses confined to 39 R and 47 E patients with HRV measurements at all visits or based on autoregressive modelling were confirmatory. Conclusion. In native black African patients, antihypertensive drugs modulate HRV, an index of autonomous nervous tone. However, these effects were mediated by changes in heart rate except for low-frequency variability, which was reduced on beta blockade independent of heart rate. © 2014 Scandinavian Foundation for Cardiovascular Research.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4059227/bin/BLO-23-174-s1.pdf
Authors & Co-Authors
Osakwe, C. E.
Belgium, Leuven
Departement Cardiovasculaire Wetenschappen
Nigeria, Wuse
National Biotechnology Development Agency, Nigeria
Jacobs, Lotte
Belgium, Leuven
Departement Cardiovasculaire Wetenschappen
Anisiuba, Benedict Chukwuemeka
Nigeria, Naukka
University of Nigeria
Ndiaye, Mouhamadou Bamba
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Lemogoum, Daniel
Cameroon, Douala
Douala School of Medicine
Ijoma, Chinwuba K.
Nigeria, Naukka
University of Nigeria
Kamdem, Marius K.
Cameroon, Douala
Douala School of Medicine
Thijs, Lutgarde B.
Belgium, Leuven
Departement Cardiovasculaire Wetenschappen
Boombhi, Hilaire J.
Cameroon, Yaounde
Yaounde General Hospital
Kaptue, Joseph
Cameroon, Douala
Douala School of Medicine
Kolo, Phillip Manma
Nigeria, Ilorin
University of Ilorin
Mipinda, Jean Bruno
Gabon, Libreville
Centre Hospitalier de Libreville
Odili, Augustine Nonso
Belgium, Leuven
Departement Cardiovasculaire Wetenschappen
Nigeria, Abuja
University of Abuja
Ezeala-Adikaibe, Birinus
Nigeria, Naukka
University of Nigeria
Kingue, Samuel
Cameroon, Yaounde
Yaounde General Hospital
Omotoso, Babatunde A.
Nigeria, Ilorin
University of Ilorin
Bâ, Serigne Abdou
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Ulasi, Ifeoma I.
Nigeria, Naukka
University of Nigeria
M'Buyamba-Kabangu, Jean René
Congo, Leuven
University Hospital of Kinshasa
Staessen, Jan A.
Belgium, Leuven
Departement Cardiovasculaire Wetenschappen
Netherlands, Maastricht
Universiteit Maastricht
Statistics
Citations: 20
Authors: 20
Affiliations: 11
Identifiers
Doi:
10.3109/08037051.2013.836810
ISSN:
08037051
e-ISSN:
16511999
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial