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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Diabetes and Pre-Diabetes among Persons Aged 35 to 60 Years in Eastern Uganda: Prevalence and Associated Factors
PLoS ONE, Volume 8, No. 8, Article e72554, Year 2013
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Description
Background:Our aim was to estimate the prevalence of abnormal glucose regulation (AGR) (i.e. diabetes and pre-diabetes) and its associated factors among people aged 35-60 years so as to clarify the relevance of targeted screening in rural Africa.Methods:A population-based survey of 1,497 people (786 women and 711 men) aged 35-60 years was conducted in a predominantly rural Demographic Surveillance Site in eastern Uganda. Participants responded to a lifestyle questionnaire, following which their Body Mass Index (BMI) and Blood Pressure (BP) were measured. Fasting plasma glucose (FPG) was measured from capillary blood using On-Call® Plus (Acon) rapid glucose meters, following overnight fasting. AGR was defined as FPG ≥6.1mmol L-1 (World Health Organization (WHO) criteria or ≥5.6mmol L-1 (American Diabetes Association (ADA) criteria. Diabetes was defined as FPG >6.9mmol L-1, or being on diabetes treatment.Results:The mean age of participants was 45 years for men and 44 for women. Prevalence of diabetes was 7.4% (95%CI 6.1-8.8), while prevalence of pre-diabetes was 8.6% (95%CI 7.3-10.2) using WHO criteria and 20.2% (95%CI 17.5-22.9) with ADA criteria. Using WHO cut-offs, the prevalence of AGR was 2 times higher among obese persons compared with normal BMI persons (Adjusted Prevalence Rate Ratio (APRR) 1.9, 95%CI 1.3-2.8). Occupation as a mechanic, achieving the WHO recommended physical activity threshold, and higher dietary diversity were associated with lower likelihood of AGR (APRR 0.6, 95%CI 0.4-0.9; APRR 0.6, 95%CI 0.4-0.8; APRR 0.5, 95%CI 0.3-0.9 respectively). The direct medical cost of detecting one person with AGR was two US dollars with ADA and three point seven dollars with WHO cut-offs.Conclusions:There is a high prevalence of AGR among people aged 35-60 years in this setting. Screening for high risk persons and targeted health education to address obesity, insufficient physical activity and non-diverse diets are necessary. © 2013 Mayega et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3743823/bin/pone.0072554.s001.docx
Authors & Co-Authors
Mayega, Roy William
Sweden, Stockholm
Karolinska Institutet
Uganda, Kampala
Makerere University School of Public Health
Guwatudde, David
Uganda, Kampala
Makerere University School of Public Health
Makumbi, Fredrick Edward
Uganda, Kampala
Makerere University School of Public Health
Nakwagala, Frederick Nelson
Uganda, Kampala
Mulago National Referral Hospital
Peterson, Stefan Swartling
Sweden, Stockholm
Karolinska Institutet
Sweden, Uppsala
Uppsala Universitet
Uganda, Kampala
Makerere University School of Public Health
Tomson, Göran B.
Sweden, Stockholm
Karolinska Institutet
Östenson, Claes Göran
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 105
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0072554
e-ISSN:
19326203
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Uganda
Participants Gender
Male
Female