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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genetic diversity and phylogeography of cassava mosaic viruses in Kenya
Journal of General Virology, Volume 87, No. 10, Year 2006
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Description
Cassava is a major factor in food security across sub-Saharan Africa. However, the crop is susceptible to losses due to biotic stresses, in particular to viruses of the genus Begomovirus (family Geminiviridae) that cause cassava mosaic disease (CMD). During the 1990s, an epidemic of CMD severely hindered cassava production across eastern and central Africa. A significant influence on the appearance of virus epidemics is virus diversity. Here, a survey of the genetic diversity of CMD-associated begomoviruses across the major cassava-growing areas of Kenya is described. Because an initial PCR-restriction fragment-length polymorphism analysis identified a much greater diversity of viruses than assumed previously, representative members of the population were characterized by sequence analysis. The full-length sequences of 109 components (68 DNA-A and 41 DNA-B) were determined, representing isolates of East African cassava mosaic virus and East African cassava mosaic Zanzibar virus, as well as a novel begomovirus species for which the name East African cassava mosaic Kenya virus is proposed. The DNA-B components were much less diverse than their corresponding DNA-A components, but nonetheless segregated into western and eastern (coastal) groups. All virus species and strains encountered showed distinct geographical distributions, highlighting the importance of preventing both the movement of viruses between these regions and the importation of the disease from adjacent countries and islands in the Indian Ocean that would undoubtedly encourage further diversification. © 2006 SGM.
Authors & Co-Authors
Bull, Simon E.
United Kingdom, Norwich
John Innes Centre
United Kingdom, Bath
University of Bath
Briddon, Rob William
United Kingdom, Norwich
John Innes Centre
Pakistan, Faisalabad
National Institute for Biotechnology and Genetic Engineering Pakistan
Sserubombwe, William S.
United Kingdom, Norwich
John Innes Centre
Ngugi, Kahiu
Kenya, Nairobi
Kenya Agricultural Research Institute
Kenya, Nairobi
University of Nairobi
Markham, Peter G.
United Kingdom, Norwich
John Innes Centre
Stanley, John
United Kingdom, Norwich
John Innes Centre
Statistics
Citations: 130
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1099/vir.0.82013-0
ISSN:
00221317
Research Areas
Food Security
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Kenya