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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Association studies in QTL regions linked to bovine trypanotolerance in a West African crossbred population
Animal Genetics, Volume 43, No. 2, Year 2012
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Description
African animal trypanosomosis is a parasitic blood disease transmitted by tsetse flies and is widespread in sub-Saharan Africa. West African taurine breeds have the ability, known as trypanotolerance, to limit parasitaemia and anaemia and remain productive in enzootic areas. Several quantitative trait loci (QTL) underlying traits related to trypanotolerance have been identified in an experimentally infected F2 population resulting from a cross between taurine and zebu cattle. Although this information is highly valuable, the QTL remain to be confirmed in populations subjected to natural conditions of infection, and the corresponding regions need to be refined. In our study, 360 West African cattle were phenotyped for the packed cell volume control under natural conditions of infection in south-western Burkina Faso. Phenotypes were assessed by analysing data from previous cattle monitored over 2 years in an area enzootic for trypanosomosis. We further genotyped for 64 microsatellite markers mapping within four previously reported QTL on BTA02, BTA04, BTA07 and BTA13. These data enabled us to estimate the heritability of the phenotype using the kinship matrix between individuals computed from genotyping data. Thus, depending on the estimators considered and the method used, the heritability of anaemia control ranged from 0.09 to 0.22. Finally, an analysis of association identified an allele of the MNB42 marker on BTA04 as being strongly associated with anaemia control, and a candidate gene, INHBA, as being close to that marker. © 2011 Stichting International Foundation for Animal Genetics.
Authors & Co-Authors
Dayo, Guiguigbaza Kossigan
France, Montpellier
Interactions Hôtes-vecteurs-parasites-environnement Dans Les Maladies Tropicales Négligées Dues Aux Trypanosomatides Intertryp
Burkina Faso, Rue
Cirdes
Gautier, Mathieu
France, Montferrier-sur-lez
Centre de Biologie Pour la Gestion Des Populations Cbgp
Berthier, David
France, Paris
Cirad
Poivey, Jean Paul
France, Paris
Cirad
France, Castanet-tolosan
Inrae Occitanie-toulouse Centre
Sidibé, Issa
Burkina Faso, Rue
Cirdes
Bengaly, Zakaria
Burkina Faso, Rue
Cirdes
Eggen, André
France, Jouy-en-josas
Génétique Animale et Biologie Intégrative
United Kingdom, Reigate United
Uk Ltd
Boichard, Didier A.
France, Jouy-en-josas
Génétique Animale et Biologie Intégrative
Thévenon, Sophie
France, Paris
Cirad
Statistics
Citations: 18
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1111/j.1365-2052.2011.02227.x
ISSN:
02689146
e-ISSN:
13652052
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Burkina Faso