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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya
Nephrology Dialysis Transplantation, Volume 22, No. 8, Year 2007
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Description
Background. Several commonly used antiretrovirals (ARVs) require dose adjustments to prevent toxicities in the presence of renal insufficiency. Because no prospective studies of the prevalence or risk factors for kidney disease in stable outpatient human immunodeficiency virus (HIV)-infected indigenous African populations have been published to date, it is not known if already scarce resources should be allocated to detect renal dysfunction, in those without risk factors for kidney disease, prior to initiation of increasingly available antiretrovirals in developing countries. Methods. A cross-sectional study to determine the prevalence of and risk factors for renal disease in a cohort of medically stable, HIV-infected, antiretroviral-naïve adults, without diabetes or hypertension, presenting to an HIV clinic in western Kenya. Results. Of 373 patients with complete data, renal insufficiency (CrCl <60 ml/min) was identified in 43 (11.5%) [18 (4.8%) had a CrCl <50 ml/min]. Despite high correlation coefficients between the three renal function estimating equations used, when compared to creatinine clearance as calculated by Cockcroft-Gault, lower rates of moderate to severe renal insufficiency were identified by the Modification of Diet in Renal Disease equations. Proteinuria, defined as a urine dipstick protein of equal to or greater than 1+, was detected in only 23 subjects (6.2%). Conclusions. Renal insufficiency is not uncommon, even in stable patients without diabetes or hypertension. Conversely, proteinuria was unexpectedly infrequent in this population. Utilizing resources to assess renal function prior to initiation of antiretrovirals in order to identify those likely to benefit from dosage adjustment is justified. © The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Authors & Co-Authors
Wools-Kaloustian, Kara K.
United States, Indianapolis
Indiana University School of Medicine
Kenya, Eldoret
Moi University
Gupta, Samir K.
United States, Indianapolis
Indiana University School of Medicine
Muloma, Eva
United States, Indianapolis
Indiana University School of Medicine
Owino-Ong'or, Willis
Kenya, Eldoret
Moi University
Sidle, John E.
United States, Indianapolis
Indiana University School of Medicine
Kenya, Eldoret
Moi University
Aubrey, Ryan W.
United States, Indianapolis
Indiana University School of Medicine
Shen, Jianzhao
United States, Indianapolis
Indiana University School of Medicine
Kipruto, Kirwa
Kenya, Eldoret
Moi University
Zwickl, Beth W.
United States, Indianapolis
Indiana University School of Medicine
Goldman, Mitchell
United States, Indianapolis
Indiana University School of Medicine
Statistics
Citations: 107
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1093/ndt/gfm223
ISSN:
09310509
e-ISSN:
14602385
Research Areas
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Kenya