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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Mortality of young patients with diabetes in Kinshasa, DR Congo
Diabetic Medicine, Volume 27, No. 4, Year 2010
Notification
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Description
Aims As data on mortality of young patients with diabetes is not available in the Democratic Republic of Congo (DRC), we studied mortality rates, the influence of some determinants and causes of death. Methods A retrospective review of standardized medical records of all patients with diabetes aged ≤ 30 years at diagnosis who were enrolled between 1994 and 2004 in a large, integrated healthcare network in Kinshasa, DRC. Diabetes was diagnosed clinically. As resources for classification according to type of diabetes were not available, the study sample was a mixed-type cohort. Death was established by review of medical records and by community interview. Mortality was recorded until 2007. Overall mortality rates and 95% confidence intervals (CI) were calculated. Kaplan-Meier survival and Cox regression analyses were performed to study the influence of determinants. Results Of the patients, 17.4% (159/915) died, mostly during the first 5 years of follow-up. Mean yearly mortality was 3.62/100 patient-years (95% CI 3.1-4.2). Independent predictors were male gender [hazard ratio (HR) 0.66 (95% CI 0.5-0.9) for females vs. males] and age at diagnosis (HR 0.97 (95% CI 0.94-0.99) per increase of 1 year]. Major causes of death were ketoacidosis (38%) and infection (12%). Cause of death was unknown in 31% of cases. Conclusions One out of six patients died, most within 5 years after diagnosis. Death occurred more frequently at home, in male patients and in subjects aged ≤ 20 years. The major cause of death was ketoacidosis. © 2010 Diabetes UK.
Authors & Co-Authors
Muyer, Muel Telo Marie Claire
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Buntinx, Frank Jvm
Belgium, Leuven
Ku Leuven
Netherlands, Maastricht
Universiteit Maastricht
Mapatano, Mala Ali
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
De Clerck, M.
Unknown Affiliation
Truyers, Carla
Belgium, Leuven
Ku Leuven
Muls, Erik
Belgium, Leuven
Ku Leuven
Statistics
Citations: 16
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1464-5491.2010.02961.x
ISSN:
07423071
e-ISSN:
14645491
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Study Locations
Congo
Participants Gender
Male
Female