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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical and diagnostic value of ribosomal P autoantibodies in systemic lupus erythematosus
Rheumatology, Volume 48, No. 8, Year 2009
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Description
Objective. To analyse prospectively the diagnostic sensitivity and specificity as well as the clinical relevance of ribosomal P (anti-P) autoantibodies in a large cohort of SLE patients. Methods. The anti-P autoantibodies were evaluated in the serum of 200 Tunisian SLE patients at disease onset and 130 various control subjects by a sensitive immunodot assay. A complete laboratory evaluation and clinical examination were performed in each SLE patient. During the follow-up, the patients were regularly monitored for clinical parameters. Global SLE activity was measured by the ECLAM. Results. The sensitivity and specificity of anti-P testing for SLE were 23.5 and 98.4%, respectively. The anti-P-positive samples 14/47 (29.8%), 27/47 (57.4%) and 5/47 (10.6%) were negative for anti-dsDNA, anti-Sm or both antibodies, respectively. The anti-P-positive patients showed more active disease activity and a much higher prevalence of arthritis. An association between IgG aCLs and anti-P antibodies was also found. However, anti-P antibodies were not associated with neuropsychiatric manifestations or lupus nephritis. Conclusion. This study does not seem to confirm the described association of anti-P antibodies with neuropsychiatric manifestations of SLE. However, it supports the anti-P antibody association with arthritis and disease activity as well as the presence of aCL. Based on our study and other related studies, we propose that, akin to anti-Sm and anti-dsDNA, anti-P antibodies detected by one agreed method may be considered for inclusion as a criterion for the classification of SLE. © The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Authors & Co-Authors
Haddouk, Samy
Tunisia, Sfax
Chu Habib Bourguiba
Marzouk, Sameh
Tunisia, Sfax
Chu Hedi-chaker
Jallouli, Moez
Tunisia, Sfax
Chu Hedi-chaker
Fourati, Hajer
Tunisia, Sfax
Chu Habib Bourguiba
Frigui, Makram
Tunisia, Sfax
Chu Hedi-chaker
Hmida, Youssef Ben Haj
Tunisia, Sfax
Chu Habib Bourguiba
Koubaa, Faten
Tunisia, Sfax
Chu Habib Bourguiba
Sellami, Wassim
Tunisia, Sfax
Chu Hedi-chaker
Baklouti, Soufiene
Tunisia, Sfax
Chu Hedi-chaker
Hachicha, Jamil
Tunisia, Sfax
Chu Hedi-chaker
Bahloul, Zouhir
Tunisia, Sfax
Chu Hedi-chaker
Masmoudi, Hatem
Tunisia, Sfax
Chu Habib Bourguiba
Statistics
Citations: 46
Authors: 12
Affiliations: 2
Identifiers
Doi:
10.1093/rheumatology/kep142
ISSN:
14620324
e-ISSN:
14620332
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study