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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
T-lymphocyte subsets in idiopathic dilated cardiomyopathy
The American Journal of Cardiology, Volume 55, No. 6, Year 1985
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Description
Idiopathic dilated cardiomyopathy (IDC) is a common clinical problem in Africa. To determine if there is a defect of immune regulation in patients with IDC, the percentage of total T-cells (OKT3 positive), helper/inducer cells (OKT4 positive) and suppressor/cytotoxic cells (OKT8 positive) were measured using monoclonal antibodies in 20 patients with IDC and in 20 age-matched normal control subjects. The percentage of helper/inducer cells was significantly higher in the IDC patients (45 ±2% mean ± standard error) than in the normal subjects (33 ± 2%) and 8 of the 20 IDC patients had a helper/suppressor cell ratio ( OKT4 OKT8) higher than the normal range. Of the 8 patients with this abnormality, 7 were studied within 3 months of the onset of their illness. Results suggest that an excessive immune reaction is part of the pathogenesis of IDC in Africans. © 1985.
Authors & Co-Authors
Sanderson, John Elsby
United Kingdom, London
St Mary's Hospital
Kenya, Nairobi
University of Nairobi Medical School
Kenya, Nairobi
Kenya Medical Research Institute
Koech, David Kiprotich
United Kingdom, London
St Mary's Hospital
Kenya, Nairobi
University of Nairobi Medical School
Kenya, Nairobi
Kenya Medical Research Institute
Iha, David W.
United Kingdom, London
St Mary's Hospital
Kenya, Nairobi
University of Nairobi Medical School
Kenya, Nairobi
Kenya Medical Research Institute
Ojiambo, Hillary P.
United Kingdom, London
St Mary's Hospital
Kenya, Nairobi
University of Nairobi Medical School
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 72
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/0002-9149(85)90151-1
ISSN:
00029149