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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
T-Helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: The multi-ethnic study of atherosclerosis
Journal of the American Heart Association, Volume 2, No. 3, Article e000117, Year 2013
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Description
Background--Although T-helper type 1 (Th1) cells are considered important in atherosclerosis, the relationships between Th1 and Th2 cells and atherosclerosis have not been examined in population-based studies. Methods and Results--We measured Th cells as a percentage of lymphocytes by flow cytometry using CD4 staining (%CD4) in 917 participants of the Multi-Ethnic Study of Atherosclerosis. We also measured interferon gamma-positive and interleukin-4-positive CD4+ cells, representing Th1 and Th2 subpopulations (%Th1 and %Th2), respectively. We found that %CD4 was 1.5% lower per 10 years of age (P<0.0001). Whites had higher %CD4 and lower %Th1 and %Th2 values than other race/ethnic groups. Body mass index (BMI) and blood pressure were associated with %CD4, but no traditional cardiovascular disease (CVD) risk factors were associated with %Th1 or %Th2. In multivariable models, the major independent variable associated with %Th1 was cytomegalovirus (CMV) antibody titer, with minor contributions from age, sex, seasonality, and interleukin-6. In models with coronary artery calcification level as the outcome, significant independent variables included age, sex, smoking status, and %Th1 (β=0.25; P≤0.01). Both %Th1 and %Th2 were associated with common carotid intimal media thickness (β=0.02 and 0.02, respectively; both P<0.05), as were age, sex, race/ethnicity, blood pressure, and BMI. Conclusions--Th1 bias is associated with subclinical atherosclerosis in a multiethnic population. The main Th1 correlate was CMV infectious burden. These findings are consistent with a role of Th1 cells in atherosclerosis and suggest the importance of prospective studies of T-helper cell biasing in CVD. © 2013 The Authors.
Authors & Co-Authors
Tracy, Russell P.
United States, Burlington
University of Vermont Larner College of Medicine
Doyle, Margaret F.
United States, Burlington
University of Vermont Larner College of Medicine
Olson, Nels C.
United States, Burlington
University of Vermont Larner College of Medicine
Huber, Sally Ann
United States, Burlington
University of Vermont Larner College of Medicine
Jenny, Nancy Swords
United States, Burlington
University of Vermont Larner College of Medicine
Sallam, Reem M.
United States, Burlington
University of Vermont Larner College of Medicine
Saudi Arabia, Riyadh
King Saud University
Psaty, Bruce M.
United States, Seattle
University of Washington
United States, Seattle
Group Health Cooperative
Kronmal, Richard A.
United States, Seattle
University of Washington
Statistics
Citations: 64
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1161/JAHA.113.000117
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study