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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Early warning indicators for HIV drug resistance in cameroon during the year 2010
PLoS ONE, Volume 7, No. 5, Article e36777, Year 2012
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Description
Background: Rapid scale-up of antiretroviral therapy (ART) in resource-limited settings is accompanied with an increasing risk of HIV drug resistance (HIVDR), which in turn could compromise the performance of national ART rollout programme. In order to sustain the effectiveness of ART in a resource-limited country like Cameroon, HIVDR early warning indicators (EWI) may provide relevant corrective measures to support the control and therapeutic management of AIDS. Methods: A retrospective study was conducted in 2010 among 40 ART sites (12 Approved Treatment Centers and 28 Management Units) distributed over the 10 regions of Cameroon. Five standardized EWIs were selected for the evaluation using data from January through December, among which: (1) Good ARV prescribing practices: target = 100%; (2) Patient lost to follow-up: target ≤20%; (3) Patient retention on first line ART: target ≥70%; (4) On-time drug pick-up: target ≥90%; (5) ARV drug supply continuity: target = 100%. Analysis was performed using a Data Quality Assessment tool, following WHO protocol. Results: The number of sites attaining the required performance are: 90% (36/40) for EWI1, 20% (8/40) for EWI2; 20% (8/40) for EWI3; 0% (0/37) for EWI4; and 45% (17/38) for EWI 5. ARV prescribing practices were in conformity with the national guidelines in almost all the sites, whereas patient adherence to ART (EWI2, EWI3, and EWI4) was very low. A high rate of patients was lost-to-follow-up and others failing first line ART before 12 months of initiation. Discontinuity in drug supply observed in about half of the sites may negatively impact ARV prescription and patient adherence. These poor ART performances may also be due to low number of trained staff and community disengagement. Conclusions: The poor performance of the national ART programme, due to patient non-adherence and drug stock outs, requires corrective measures to limit risks of HIVDR emergence in Cameroon. © 2012 Billong et al.
Authors & Co-Authors
Billong, Serge Clotaire
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Université de Yaoundé I
Fokam, Joseph
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Nkwescheu, Armand Séraphin
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Ministry of Public Health Cameroon
Kembou, Etienne
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
World Health Organisation
Milenge, Pascal
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
World Health Organisation
Tsomo, Zephirin
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Dion, Grace Ngute
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Yaounde General Hospital
Aghokeng, Avelin Fobang
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
Centre de Recherche en Maladies Emergentes et Re-emergentes Cremer
Mpoudi, Eitel N.
Cameroon, Yaounde
Centre de Recherche en Maladies Emergentes et Re-emergentes Cremer
Ndumbe, Peter Martins
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Cameroon, Buea
University of Buea
Colizzi, Vittorio C.
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Nfetam, Jean Bosco Elat
Cameroon, Yaounde
National Hiv Drug Resistance Prevention and Surveillance Working Group
Cameroon, Yaounde
Ministry of Public Health Cameroon
Statistics
Citations: 12
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pone.0036777
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Approach
Systematic review
Study Locations
Cameroon