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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Interpretation of negative molecular test results in patients with suspected or confirmed ebola virus disease: Report of two cases
Open Forum Infectious Diseases, Volume 2, No. 4, Year 2015
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Description
Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) is the most sensitive quantitative diagnostic assay for detection of Ebola virus in multiple body fluids. Despite the strengths of this assay, we present 2 cases of Ebola virus disease (EVD) and highlight the potential for false-negative results during the early and late stages of EVD. The first case emphasizes the low negative-predictive value of qRTPCR during incubation and the early febrile stage of EVD, and the second case emphasizes the potential for falsenegative results during recovery and late neurologic complications of EVD. Careful interpretation of test results are needed to guide difficult admission and discharge decisions in suspected or confirmed EVD. © The Author 2015.
Authors & Co-Authors
Edwards, Jeffrey Karl
Belgium, Brussels
Medecins Sans Frontieres, Brussels
United States, Baltimore
Johns Hopkins University
Kleine, Christian
Belgium, Brussels
Medecins Sans Frontieres, Brussels
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Munster, Vincent J.
United States, Bethesda
National Institutes of Health Nih
Giuliani, Ruggero
Belgium, Brussels
Medecins Sans Frontieres, Brussels
Massaquoi, Moses B.F.
United States, Boston
Clinton Health Access Initiative, Inc.
Sprecher, Armand G.
Belgium, Brussels
Medecins Sans Frontieres, Brussels
Chertow, Daniel S.
Belgium, Brussels
Medecins Sans Frontieres, Brussels
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 11
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1093/ofid/ofv137
ISSN:
23288957
Research Areas
Infectious Diseases
Study Approach
Quantitative