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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants
Proceedings of the National Academy of Sciences of the United States of America, Volume 104, No. 43, Year 2007
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Description
Over the last 30 years, Zaire ebolavirus (ZEBOV), a virus highly pathogenic for humans and wild apes, has emerged repeatedly in Central Africa. Thus far, only a few virus isolates have been characterized genetically, all belonging to a single genetic lineage and originating exclusively from infected human patients. Here, we describe the first ZEBOV sequences isolated from great ape carcasses in the Gabon/Congo region that belong to a previously unrecognized genetic lineage. According to our estimates, this lineage, which we also encountered in the two most recent human outbreaks in the Republic of the Congo in 2003 and 2005, diverged from the previously known viruses around the time of the first documented human outbreak in 1976. These results suggest that virus spillover from the reservoir has occurred more than once, as predicted by the multiple emergence hypothesis. However, the young age of both ZEBOV lineages and the spatial and temporal sequence of outbreaks remain at odds with the idea that the virus simply emerged from a long-established and widespread reservoir population. Based on data from two ZEBOV genes, we also demonstrate, within the family Filoviridae, recombination between the two lineages. According to our estimates, this event took place between 1996 and 2001 and gave rise to a group of recombinant viruses that were responsible for a series of outbreaks in 2001-2003. The potential for recombination adds an additional level of complexity to unraveling and potentially controlling the emergence of ZEBOV in humans and wildlife species. © 2007 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2040453/bin/pnas_0704076104_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2040453/bin/pnas_0704076104_2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2040453/bin/pnas_0704076104_3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2040453/bin/pnas_0704076104_1.pdf
Authors & Co-Authors
Wittmann, Tatiana J.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Biek, Roman
United States, Atlanta
Emory University
Hassanin, Alexandre
France, Paris
Cnrs Centre National de la Recherche Scientifique
Rouquet, Pierre
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Reed, Patricia E.
United States, New York
Wildlife Conservation Society
Yaba, Philippe
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Pourrut, Xavier
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Real, Leslie A.
United States, Atlanta
Emory University
Gonzalez, J. P.
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Glasgow
University of Glasgow
Leroy, Éric Maurice
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Statistics
Citations: 103
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1073/pnas.0704076104
ISSN:
00278424
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Congo
Gabon