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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Treatment of intestinal helminths does not reduce plasma concentrations of HIV-1 RNA in coinfected Zambian adults
Journal of Infectious Diseases, Volume 192, No. 7, Year 2005
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Description
Background. Infection with intestinal helminths may stimulate dysfunctional immune responses in human immunodeficiency virus (HIV)-infected persons. Studies have yielded conflicting results regarding the impact of antihelminthic treatment on plasma concentrations of HIV-1 RNA. Methods. We conducted a prospective study of 54 HIV-1- and helminth-coinfected and 57 HIV-1-infected, helminth-uninfected asymptomatic adults living in Lusaka, Zambia, to assess the impact of antihelminthic treatment on plasma concentrations of HIV-1 RNA. Results. Median baseline viral load was 0.33 log10 copies/mL lower in the helminth-infected group than in the uninfected group. Mean viral load between pretreatment and posttreatment visits increased in the helminth-infected (mean, 4.23 vs. 4.29 log10 copies/mL; P = .6) and helminth-uninfected (mean, 4.39 vs. 4.52 log10 copies/ mL; P = .2) groups. Helminth-infected participants with high pretreatment viral loads had a mean 0.25-log10 copies/mL decrease after treatment (P = .3), and helminth-uninfected participants had a mean 0.02-log10 copies/ mL decrease (P = .8). Conclusions. We did not find an overall association between treatment of intestinal helminth infections and reduction in viral load in coinfected adults. Future studies may need to focus on adults with intense helminth infections who live in rural areas or on adults or children who harbor higher helminth burdens and plasma concentrations of HIV-1 RNA. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Modjarrad, Kayvon
United States, Birmingham
The University of Alabama at Birmingham
Zulu, Isaac S.
Zambia, Lusaka
University Teaching Hospital Lusaka
Redden, David T.
United States, Birmingham
The University of Alabama at Birmingham
Njobvu, Lungowe
Zambia, Lusaka
University Teaching Hospital Lusaka
Lane, Henry Clifford
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Bentwich, Zvi
Israel, Rehovoth
Aids Center
Vermund, Sten Havlor
United States, Birmingham
The University of Alabama at Birmingham
Statistics
Citations: 70
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1086/444543
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Zambia