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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Synthesis of homochiral amino acid pyrazine and pyrrole analogues of glutamate antagonists
Journal of the Chemical Society. Perkin Transactions 1, Volume 2, No. 5, Year 2002
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Description
Use of the acid 7 and the aldehydes 23a and 23b in “ring switching” reactions with hydrazines has given β-(1-aminopyrrole)amino acids as kinetic products. The products from the reaction of the aldehyde have been converted into β-(pyrazine)amino acids by an equilibration–dehydration sequence. A variety of homochiral reduced heterocyclic amino acids containing two chiral centres has been prepared in this way. Some of the product amino acids undergo “reverse ring switching” to the corresponding pyroglutamic acid derivatives. © 2002 The Royal Society of Chemistry.
Authors & Co-Authors
Dinsmore, Andrew
United Kingdom, Brighton
University of Sussex
South Africa, Johannesburg
University of the Witwatersrand
Doyle, Paul M.
United Kingdom, Brighton
University of Sussex
United Kingdom, Saffron Walden
Biofocus Dpi Ltd
Steger, Matthias
United Kingdom, Brighton
University of Sussex
Switzerland, Allschwil
Axovan Ltd.
Young, Douglas W.
United Kingdom, Brighton
University of Sussex
Statistics
Citations: 13
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1039/b110979k
ISSN:
14727781
e-ISSN:
13645463