Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase
Bioorganic and Medicinal Chemistry Letters, Volume 22, No. 1, Year 2012
Notification
URL copied to clipboard!
Description
A new methylene-bridged bisflavonoid, methylenebissantin (1), and nine known compounds, including flavonoids (2-5), diterpenoids (6 and 7), and phenol derivatives (8-10) were isolated from the aerial parts of Dodonaea viscosa Jacq. The structure elucidation was based on spectroscopic data analyses. The isolated compounds were evaluated for the inhibition of Plasmodium falciparum enoyl-ACP reductase (PfENR). Methylenebissantin (1) exhibited a moderate inhibition (IC 50 91.13 μM) against PfENR. © 2011 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Muhammad, Akhtar
Pakistan, Karachi
University of Karachi
Anis, Itrat
Pakistan, Karachi
University of Karachi
Malik, Zulfiqar Ali
Pakistan, Karachi
University of Karachi
United States, University
University of Mississippi School of Pharmacy
Awadelkarim, Sufyan
Sudan, Khartoum
National Center for Research Sudan
Khan, Ajmal L.
Pakistan, Karachi
University of Karachi
Khalid, Asaad
Sudan, Khartoum
National Center for Research Sudan
Shah, Muhammad Raza
Pakistan, Karachi
University of Karachi
Galal, M.
Sudan, Khartoum
National Center for Research Sudan
Khan, Ikhlas A.
United States, University
University of Mississippi School of Pharmacy
Iqbal-Choudhary, Muhammad
Pakistan, Karachi
University of Karachi
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 30
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/j.bmcl.2011.10.072
ISSN:
0960894X
e-ISSN:
14643405