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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Evaluation of phytocannabinoids from high-potency Cannabis sativa using in vitro bioassays to determine structure-activity relationships for cannabinoid receptor 1 and cannabinoid receptor 2
Medicinal Chemistry Research, Volume 23, No. 9, Year 2014
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Description
Cannabis has been around for thousands of years and has been used recreationally, medicinally, and for fiber. Over 500 compounds have been isolated from Cannabis sativa with approximately 105 being cannabinoids. Of those 105 compounds, Δ9-tetrahydrocannabinol has been determined as the primary constituent, which is also responsible for the psychoactivity associated with Cannabis. Cannabinoid receptors belong to the large superfamily of G protein-coupled receptors. Targeting the cannabinoid receptors has the potential to treat a variety of conditions such as pain, neurodegeneration, appetite, immune function, anxiety, cancer, and others. Developing in vitro bioassays to determine binding and functional activity of compounds has the ability to lead researchers to develop a safe and effective drug that may target the cannabinoid receptors. Using radioligand binding and functional bioassays, a structure-activity relationship for major and minor cannabinoids was developed. © 2014 Springer Science+Business Media New York.
Authors & Co-Authors
Husni, Afeef S.
United States, University
University of Mississippi
McCurdy, Christopher Robert
United States, University
University of Mississippi
Radwan, Mohamed M.
United States, University
University of Mississippi
Ahmed, Safwat A.
United States, University
University of Mississippi
Slade, Desmond
United States, University
University of Mississippi
Ross, Samir Anis
United States, University
University of Mississippi
ElSohly, Mahmoud A.
United States, University
University of Mississippi
Cutler, Stephen J.
United States, University
University of Mississippi
Statistics
Citations: 46
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1007/s00044-014-0972-6
ISSN:
10542523
Research Areas
Cancer
Mental Health
Substance Abuse