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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients
Clinical Biochemistry, Volume 43, No. 3, Year 2010
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Description
Background/aims: The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin-converting enzyme (ACE) gene polymorphisms as being risk factors for diabetes is still controversial. The aim was to investigate the distribution of ACE and MTHFR genotypes as well as to evaluate the role of plasmatic total homocysteine levels (tHcy) and ACE activity in Tunisian patients with type 2 diabetes mellitus (T2DM). Design and methods: 115 T2DM patients compared to 116 healthy volunteers. Results: The ACE I/D polymorphism was significantly associated with diabetes (p < 0.0001). The DD genotype and D allele were more frequent in patients compared to control group [DD: OR = 4.93; p < 0.0001; 95 % CI: 2.71-8.97; D: OR = 3.08, 95% CI: 2.09-4.51 p < 0.0001]. MTHFR allele and genotype frequencies did not differ between patients and controls. The susceptibility to diabetes in individuals with genotypes DD +vTT was 13.39 and in the individuals with DD + CT was 6.57 times that of the controls. However, individuals with genotypes ID + CC or II + CT have a protective effect against diabetes. The DD and TT genotypes were associated with significantly higher ACE activity and tHcy levels in diabetics. Conclusion: Our data suggest that ACE ID polymorphism may act synergistically with MTHFR C677T polymorphism to assess diabetes risk. Crown Copyright © 2009.
Authors & Co-Authors
Mehri, Sounira
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Koubaa, Nadia
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Nakbi, Amel
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Hammami, Sonia Ouali
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Tunisia, Monastir
Chu Fattouma-bourguiba
Châaba, Raja
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Mahjoub, Sinda Zarrouk
Unknown Affiliation
Zouari, Béchir
Tunisia, Tunis
Faculté de Médecine de Tunis
Abid, Mohamed Salah
Tunisia, Sfax
Chu Hedi-chaker
Ben Arab, Saïda
Unknown Affiliation
Baudin, Bruno
France, Paris
Hôpital Saint-antoine
Hammami, M. B.
Tunisia, Monastir
Ur Human Nutrition and Metabolic Disorders Faculty of Medicine
Statistics
Citations: 36
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1016/j.clinbiochem.2009.10.008
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Randomised Control Trial