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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Suppression of a novel hematopoietic mediator in children with severe malarial anemia
Infection and Immunity, Volume 77, No. 9, Year 2009
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Description
In areas of holoendemic Plasmodium falciparum transmission, severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality. Although many soluble mediators regulate erythropoiesis, it is unclear how these factors contribute to development of SMA. Investigation of novel genes dysregulated in response to malarial pigment (hemozoin [PfHz]) revealed that stem cell growth factor (SCGF; also called C-type lectin domain family member 11A [CLEC11A]), a hematopoietic growth factor important for development of erythroid and myeloid progenitors, was one of the most differentially expressed genes. Additional experiments with cultured peripheral blood mononuclear cells (PBMCs) demonstrated that PfHz decreased SCGF/CLEC11A transcriptional expression in a time-dependent manner. Circulating SCGF levels were then determined for Kenyan children (n = 90; aged 3 to 36 months) presenting at a rural hospital with various severities of malarial anemia. SCGF levels in circulation (P = 0.001) and in cultured PBMCs (P = 0.004) were suppressed in children with SMA. Circulating SCGF also correlated positively with hemoglobin levels (r = 0.241; P = 0.022) and the reticulocyte production index (RPI) (r = 0.280; P = 0.029). In addition, SCGF was decreased in children with reduced erythropoiesis (RPI of <2) (P < 0.001) and in children with elevated levels of naturally acquired monocytic PfHz (P = 0.019). Thus, phagocytosis of PfHz promotes a decrease in SCGF gene products, which may contribute to reduced erythropoiesis in children with SMA. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Keller, Christopher C.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
United States, Erie
Lake Erie College of Osteopathic Medicine
Ouma, Collins
United States, Albuquerque
The University of new Mexico
Kenya, Maseno
Maseno University
Ouma, Yamo
United States, Albuquerque
The University of new Mexico
Awandare, Gordon Akanzuwine
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Ghana, Accra
University of Ghana
Davenport, Gregory C.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
United States, Albuquerque
Unm School of Medicine
Were, Tom
United States, Albuquerque
The University of new Mexico
Hittner, James Bryant
United States, Charleston
College of Charleston
Vulule, John M.
Kenya, Nairobi
Kenya Medical Research Institute
Ong'Echa, John Michael O.
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
Unm School of Medicine
Perkins, Douglas Jay
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
Unm School of Medicine
Statistics
Citations: 26
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1128/IAI.00342-09
ISSN:
00199567
e-ISSN:
10985522
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health