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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Validation of an animal model of right ventricular dysfunction and right bundle branch block to create close physiology to postoperative tetralogy of Fallot
International Journal of Cardiology, Volume 154, No. 1, Year 2012
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Description
Background: In the past 5 years a few number of studies and case reports have come out focusing on biventricular (BiV) stimulation for treatment of congenital heart disease related ventricular dysfunction. The few available studies include a diverse group of pathophysiological entities ranging from a previously repaired tetralogy of Fallot (TOF) to a functional single ventricle anatomy. Patient's status is too heterogeneous to build important prospective study. To well understand the implication of prolonged electromechanical dyssynchrony we performed a chronic animal model that mimics essential parameters of postoperative TOF. Methods: Significant pulmonary regurgitation, mild stenosis, as well as right ventricular outflow tract (RVOT) scars were induced in 15 piglets to mimic repaired TOF. 4 months after hemodynamics and dyssynchrony parameters were compared with a control group and with a population of symptomatic adult with repaired TOF. Results: Comparing the animal model with the animal control group on echocardiography, RV dilatation, RV and LV dysfunction, broad QRS complex and dyssynchrony were observed on the animal model piglets. Moreover, epicardial electrical mapping showed activation consistent with a right bundle branch block. The animal models displayed the same pathophysiological parameters as the post TOF repair patients in terms of QRS duration, pulmonary regurgitation biventricular dysfunction and dyssynchrony. Conclusion: This chronic swine model mimics electromechanical ventricular activation delay, RV and LV dysfunction, as in adult population of repair TOF. It does appear to be a very useful and interesting model to study the implication of dyssynchrony and the interest of resynchronization therapy in TOF failing ventricle. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Thambo, Jean Benoît
France, Talence
Centre Hospitalier Universitaire de Bordeaux
France, Paris
Inserm
Roubertie, François
France, Talence
Centre Hospitalier Universitaire de Bordeaux
de Guillebon, Maxime
France, Bordeaux
Université de Bordeaux
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Labrousse, Louis M.
France, Talence
Centre Hospitalier Universitaire de Bordeaux
France, Paris
Inserm
Iriart, Xavier
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Ntsinjana, Hopewell N.
South Africa, Johannesburg
University of the Witwatersrand
Lafitte, Stéphane
France, Talence
Centre Hospitalier Universitaire de Bordeaux
France, Paris
Inserm
Ploux, Sylvain
France, Bordeaux
Université de Bordeaux
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Haïssaguerre, Michel
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Roques, Xavier F.
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Dos Santos, Pierre Alexandre Lexandre
France, Bordeaux
Université de Bordeaux
France, Talence
Centre Hospitalier Universitaire de Bordeaux
France, Paris
Inserm
Bordachar, Pierre
France, Talence
Centre Hospitalier Universitaire de Bordeaux
France, Paris
Inserm
Statistics
Citations: 15
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.ijcard.2010.08.063
ISSN:
01675273
e-ISSN:
18741754
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study