Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Iron chelation in thalassemia: Combined or monotherapy? The Egyptian experience
Annals of Hematology, Volume 87, No. 7, Year 2008
Notification
URL copied to clipboard!
Description
Patients with thalassemia major requiring regular blood transfusions accumulate iron that is toxic to the heart, liver, and endocrine systems. The following prospective, randomized trial was carried out to determine the effectiveness, in children and young adults, of combined deferiprone (DFP) and deferoxamine (DFO) in reducing transfusional iron overload compared to either drug alone and to assess the safety and tolerability of DFP. Sixty-six patients were randomized into three treatment arms: daily DFP combined with DFO twice weekly; daily DFP only; and DFO only 5 days/week. Fifty-six patients completed the 54 weeks and were assessed by different indices. A significant reduction of liver iron concentration and serum ferritin was observed in all three arms while significant reduction of liver iron score was observed in patients on combination therapy only. Cardiac function did not significantly change in any arm. Compliance improved in patients who received combined therapy. Toxicity of DFP was mild to moderate and acceptable; most commonly, transient arthropathy and nausea/vomiting were observed. Thus, combination therapy has shown to be effective in reducing iron overload in thalassemia patients. © Springer-Verlag 2008.
Authors & Co-Authors
El-Beshlawy, Amal M.
Egypt, Cairo
Faculty of Medicine
Manz, Chantal
Switzerland, Arlesheim
Lipomed ag
Naja, Mohammed
Lebanon, Beirut
American University of Beirut Medical Center
Eltagui, Mona
Egypt, Cairo
Faculty of Medicine
Tarabishi, Claudia
Egypt, Cairo
Faculty of Medicine
Youssry, Ilham
Egypt, Cairo
Faculty of Medicine
Sobh, Hewida
Egypt, Cairo
Faculty of Medicine
Hamdy, Mona Mohamed
Egypt, Cairo
Faculty of Medicine
Sharaf, Iman
Egypt, Cairo
Faculty of Medicine
Ibrahim, Azza Mostafa
Egypt, Cairo
Faculty of Medicine
Shaker, O. Gamil
Egypt, Cairo
Faculty of Medicine
Hoffbrand, Allan Victor
United Kingdom, London
The Royal Free Hospital
Taher, Ali T.
Lebanon, Beirut
American University of Beirut Medical Center
Lebanon, Hazmieh
Chronic Care Center, Hazmieh
Statistics
Citations: 46
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1007/s00277-008-0471-2
ISSN:
09395555
Research Areas
Environmental
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study