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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study
Movement Disorders, Volume 23, No. 11, Year 2008
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Description
The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD. © 2008 Movement Disorder Society.
Authors & Co-Authors
Latourelle, Jeanne C.
United States, Boston
Boston University
MacDonald, Marcy E.
United States, Boston
Massachusetts General Hospital
Suchowersky, Oksana
Canada, Calgary
University of Calgary
Klein, Christine
Germany, Lubeck
Universität zu Lübeck
Watts, Ray L.
United States, Birmingham
The University of Alabama at Birmingham
Guttman, Mark
Canada, Toronto
University of Toronto
Racette, Brad A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Perlmutter, Joel S.
United States, St. Louis
Washington University School of Medicine in St. Louis
Ahmed, Anwar
United States, Phoenix
Barrow Neurological Institute
DeStefano, Anita L.
United States, Boston
Boston University
Mysore, Jayalakshmi Srinidhi
United States, Boston
Massachusetts General Hospital
Goldwurm, S.
Italy, Milan
Istituti Clinici Di Perfezionamento
PEZZOLI, GIANNI
Italy, Milan
Istituti Clinici Di Perfezionamento
Itin, Ilia
United States, Cleveland
Cleveland Clinic Foundation
Nicholson, Garth A.
Australia, Sydney
Concord Repatriation General Hospital
Nance, Martha A.
United States, Minneapolis
Park Nicollet Clinic
Burn, David J.
United Kingdom, Newcastle
Newcastle University
Chinnery, Patrick Francis
United Kingdom, Newcastle
Newcastle University
Pramstaller, Peter P.
Italy, Bolzano
Regional Hospital of Bolzano
Roxburgh, Richard H.S.R.
New Zealand, Auckland
Auckland City Hospital
Cambi, Franca
United States, Lexington
University of Kentucky College of Medicine
Gusella, James F.
United States, Boston
Massachusetts General Hospital
Myers, Richard H.M.
United States, Boston
Boston University
Statistics
Citations: 6
Authors: 23
Affiliations: 26
Identifiers
Doi:
10.1002/mds.22186
ISSN:
15318257
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study