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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Immune response to SARS-CoV-2 variants of concern in vaccinated individuals
Nature Communications, Volume 12, No. 1, Article 3109, Year 2021
Notification
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Description
SARS-CoV-2 is evolving with mutations in the receptor binding domain (RBD) being of particular concern. It is important to know how much cross-protection is offered between strains following vaccination or infection. Here, we obtain serum and saliva samples from groups of vaccinated (Pfizer BNT-162b2), infected and uninfected individuals and characterize the antibody response to RBD mutant strains. Vaccinated individuals have a robust humoral response after the second dose and have high IgG antibody titers in the saliva. Antibody responses however show considerable differences in binding to RBD mutants of emerging variants of concern and substantial reduction in RBD binding and neutralization is observed against a patient-isolated South African variant. Taken together our data reinforce the importance of the second dose of Pfizer BNT-162b2 to acquire high levels of neutralizing antibodies and high antibody titers in saliva suggest that vaccinated individuals may have reduced transmission potential. Substantially reduced neutralization for the South African variant further highlights the importance of surveillance strategies to detect new variants and targeting these in future vaccines. © 2021, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8149389/bin/41467_2021_23473_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8149389/bin/41467_2021_23473_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8149389/bin/41467_2021_23473_MOESM3_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8149389/bin/41467_2021_23473_MOESM4_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8149389/bin/41467_2021_23473_MOESM5_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8149389/bin/41467_2021_23473_MOESM6_ESM.xlsx
Authors & Co-Authors
Becker, Matthias
Unknown Affiliation
Dulovic, Alex
Unknown Affiliation
Junker, Daniel
Unknown Affiliation
Kaiser, Philipp D.
Unknown Affiliation
Pinilla, Yudi Tatiana
Germany, Tubingen
Eberhard Karls Universität Tübingen
Heinzel, Constanze
Germany, Tubingen
Eberhard Karls Universität Tübingen
Traenkle, Bjoern
Unknown Affiliation
Wagner, Teresa R.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Held, Jana
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
German Center for Infection Research Dzif
Schenke-Layland, Katja
Germany, Tubingen
Eberhard Karls Universität Tübingen
United States, Los Angeles
David Geffen School of Medicine at Ucla
Krause, Gérard
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Germany, Hannover
Hannover Medical School
Strengert, Monika
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Germany, Hannover
Hannover Medical School
Bakchoul, Tamam
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Althaus, Karina
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Fendel, Rolf
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
German Center for Infection Research Dzif
Kreidenweiss, Andrea
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
German Center for Infection Research Dzif
Rothbauer, Ulrich
Germany, Tubingen
Eberhard Karls Universität Tübingen
Schindler, Michael
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Schneiderhan-Marra, Nicole
Unknown Affiliation
Statistics
Citations: 75
Authors: 19
Affiliations: 7
Identifiers
Doi:
10.1038/s41467-021-23473-6
ISSN:
20411723
Research Areas
Health System And Policy