Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa
Epilepsia, Volume 47, No. 5, Year 2006
Notification
URL copied to clipboard!
Description
Purpose: Cerebral malaria (CM) is suspected to be a potential cause of epilepsy in tropical areas, but little information is available. The purpose of this study was to evaluate the role of CM in epilepsy among children in Mali. Methods: An exposed-nonexposed study was performed to identify children who had epilepsy after malaria in the 0- to 15-year age group. The exposure factor was CM defined according to World Health Organization (WHO) criteria, and the nonexposure factor was symptomatic malaria without the characteristics of CM (NCM). All the children underwent a screening questionnaire and were examined by a medical physician. After the screening phase, a specialist in neuropediatrics examined the children suspected to have epilepsy. EEG and computed tomography (CT) scans were performed in some of these patients. Results: In total, 101 subjects who had had CM and 222 who had had NCM were included. Fifty-four children (CM, 34; NCM, 20) were suspected to have epilepsy, and six were confirmed (CM, five; NCM, one). The incidence rate was 17.0 per 1000 person-years in the CM group and 1.8 per 1000 person-year in the NCM group; thus the relative risk (RR) was 9.4 [95% confidence interval (CI), 1.3-80.3; p = 0.02]. After adjustment on age and duration of follow-up, the RR was 14.3 (95% CI, 1.6-132.0; p = 0.01). Conclusions: The risk of sequelar epilepsy is significantly higher in the CM group compared with the NCM group. A reevaluation of this cohort should be carried out later to search for temporal epilepsy that appeared after age 10 years. © 2006 International League Against Epilepsy.
Authors & Co-Authors
Ngoungou, Edgard Brice
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Gabon, Libreville
University of Health Sciences
Dulac, Olivier J.
France, Paris
Hôpital Necker Enfants Malades
Poudiougou, Belco
Mali, Bamako
University of Bamako
Druet-Cabanac, Michel
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Dicko, Alassane A.
Mali, Bamako
University of Bamako
Traoré, Abdoulaye Mamadou
Mali, Bamako
University of Bamako
Coulibaly, Drissa M.
Mali, Bamako
University of Bamako
Farnarier, Guy
France, Marseille
North Hospital
Tuillas, Maryse
France, Limoges
Hopital Dupuytren
Kéita, Mamadou Marouf
Mali, Bamako
Gabriel Toure Hospital
Kombila, Maryvonne Y.
Gabon, Libreville
University of Health Sciences
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Preux., Pierre Marie
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Statistics
Citations: 13
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1111/j.1528-1167.2006.00524.x
e-ISSN:
15281167
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Multi-countries
Mali