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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High prevalence of antiretroviral drug resistance among HIV-1-untreated patients in Guinea-Conakry and in Niger
Antiviral Therapy, Volume 16, No. 3, Year 2011
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Description
Background: The aim of the study was to assess the prevalence of antiretroviral drug resistance mutations in HIV-1 from recently diagnosed and untreated patients living in Conakry, Guinea-Conakry and in Niamey, Niger. Methods: The study was performed in two countries of Western Africa - Guinea-Conakry and Niger - using the same survey method in both sites. All newly HIV-1 diagnosed patients, naive of antiretroviral drugs, were consecutively included during September 2009 in each of the two sites. Protease and reverse transcriptase sequencing was performed using the ANRS procedures. Drug resistance mutations were identified according to the 2009 update surveillance drug resistance mutations. Results: In Conakry, 99 patients were included, most of whom (89%) were infected with CRF02-AG recombinant virus. Resistance analysis among the 93 samples showed that ≥1 drug resistance mutation was observed in 8 samples, leading to a prevalence of primary resistance of 8.6% (95% CI 2.91-14.29%). In Niamey, 96 patients were included; a high diversity in HIV-1 subtypes was observed with 47 (51%) patients infected with CRF02-AG. Resistance analysis performed among the 92 samples with successful genotypic resistance test showed that ≥1 drug resistance mutation was observed in 6 samples, leading to a prevalence of primary resistance of 6.5% (95% CI 1.50-11.50%). Conclusions: We reported the first antiretroviral drug resistance survey studies in antiretroviral-naive patients living in Guinea-Conakry and in Niger. The prevalence of resistance was between 6% and 9% in both sites, which is higher than most of the other countries from Western Africa region. ©2011 International Medical Press.
Authors & Co-Authors
Charpentier, Charlotte
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Bellecave, Pantxika
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Cissé, Mohamed O.
Guinea
Chu de Donka
Mamadou, Saïdou
Niger
Chu Niamey
Diakité, Mandiou
Guinea, Conakry
Chu Donka
Peytavin, Gilles
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Tchiombiano, Stéphanie
France, Paris
Solthis
Teisseire, Pierre
France, Paris
Solthis
Pizarro, Louis
France, Paris
Solthis
Storto, Alexandre
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Brun-Vézinet, Françoise
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Katlama, Christine
France, Paris
Solthis
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Calvez, Vincent
France, Paris
Solthis
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Inserm
Marcelin, Anne Geneviève
France, Paris
Solthis
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Inserm
Masquelier, Bernard
France, Talence
Centre Hospitalier Universitaire de Bordeaux
France, Paris
Solthis
Descamps, Diáne
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
France, Paris
Solthis
Statistics
Citations: 33
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.3851/IMP1754
ISSN:
13596535
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Guinea
Niger