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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Linkage of a locus for autosomal dominant familial spastic paraplegia to chromosome 2p markers
Human Molecular Genetics, Volume 3, No. 10, Year 1994
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Description
'Pure' autosomal dominant familial spastic paraplegia (SPG) is a neurodegenerative disease which clinically manifests as spasticity of the lower limbs. Dominantly inherited SPG is known to be clinically heterogenous and has been classified into late-onset and early-onset types, based on the age of onset of symptoms. We tested five autosomal dominant SPG families for genetic linkage and established linkage to chromogene 2p markers (Z(θ) = 3.65) with evidence of genetic locus heterogeneity. Three late-onset SPG families and one early-onset SPG family had high posterior probability of linkage (P>0.94) to chromosome 2p, while the fifth family (a very early-onset family) was not linked to chromosome 2 and showed high probability of linkage to chromosome 14q. These data provide a basis for a classification of SPG according to chromosome location rather than age of onset of symptoms. © 1994 Oxford University Press.
Authors & Co-Authors
Hentati, A.
United States, Chicago
Northwestern University Feinberg School of Medicine
Kunkle, Brian W.
United States, Durham
Duke University Medical Center
Lennon, F.
United States, Durham
Duke University Medical Center
Wasserman, Brad
United States, Chicago
Northwestern University Feinberg School of Medicine
Hentati, F. F.
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Juneja, Tony
United States, Chicago
Northwestern University Feinberg School of Medicine
Angrist, Misha H.
Unknown Affiliation
Hung, Wu Yen
United States, Chicago
Northwestern University Feinberg School of Medicine
Boustany, R. M.
United States, Durham
Duke University Medical Center
Bohlega, Saeed A.
United States, Cleveland
Case Western Reserve University
Iqbal, Zafar
United States, Chicago
Northwestern University Feinberg School of Medicine
Huether, Carl H.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Hamida, Mongi Ben
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
United States, Cincinnati
University of Cincinnati
Siddique, Teepu S.
United States, Chicago
Northwestern University Feinberg School of Medicine
United States, Cincinnati
University of Cincinnati
Statistics
Citations: 113
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1093/hmg/3.10.1867
ISSN:
09646906
Research Areas
Genetics And Genomics