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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genomics of an emerging clone of Salmonella serovar Typhimurium ST313 from Nigeria and the Democratic Republic of Congo
Journal of Infection in Developing Countries, Volume 7, No. 10, Year 2013
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Description
Introduction: Salmonella enterica serovar Typhimurium ST313 is an invasive and phylogenetically distinct lineage present in sub-Saharan Africa. We report the presence of S. Typhimurium ST313 from patients in the Democratic Republic of Congo and Nigeria. Methodology: Eighteen S. Typhimurium ST313 isolates were characterized by antimicrobial susceptibility testing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). Additionally, six of the isolates were characterized by whole genome sequence typing (WGST). The presence of a putative virulence determinant was examined in 177 Salmonella isolates belonging to 57 different serovars. Results: All S. Typhimurium ST313 isolates harbored resistant genes encoded by blaTEM1b, catA1, strA/B, sul1, and dfrA1. Additionally, aac(6')1aa gene was detected. Phylogenetic analyses revealed close genetic relationships among Congolese and Nigerian isolates from both blood and stool. Comparative genomic analyses identified a putative virulence fragment (ST313-TD) unique to S. Typhimurium ST313 and S. Dublin. Conclusion: We showed in a limited number of isolates that S. Typhimurium ST313 is a prevalent sequence-type causing gastrointestinal diseases and septicemia in patients from Nigeria and DRC. We found three distinct phylogenetic clusters based on the origin of isolation suggesting some spatial evolution. Comparative genomics showed an interesting putative virulence fragment (ST313-TD) unique to S. Typhimurium ST313 and invasive S. Dublin. © 2013 Leekitcharoenphon et al.
Authors & Co-Authors
Leekitcharoenphon, Pimlapas
Denmark, Lyngby
Technical University of Denmark
Friis, Carsten
Denmark, Lyngby
Technical University of Denmark
Zankari, Ea
Denmark, Lyngby
Technical University of Denmark
Svendsen, Christina Aaby
Denmark, Lyngby
Technical University of Denmark
Price, Lance L. B.
United States, Phoenix
Translational Genomics Research Institute
Rahmani, Maral
Denmark, Lyngby
Technical University of Denmark
Herrero-Fresno, Ana
Denmark, Lyngby
Technical University of Denmark
Fashae, Kayode F.
Nigeria, Ibadan
University of Ibadan
Vandenberg, Olivier
Belgium, Brussels
Université Libre de Bruxelles
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Aarestrup, Frank Møller
Denmark, Lyngby
Technical University of Denmark
Hendriksen, Rene Sjøgren
Denmark, Lyngby
Technical University of Denmark
Statistics
Citations: 38
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.3855/jidc.3328
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Congo
Nigeria