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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Prostate cancer genetic risk and associated aggressive disease in men of African ancestry
Nature Communications, Volume 14, No. 1, Article 8037, Year 2023
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Description
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common risk variants contributing to a multiethnic polygenic risk score, with rare variants focused on a panel of roughly 20 pathogenic genes. Based on this knowledge, we are unable to determine polygenic risk or differentiate prostate cancer status interrogating whole genome data for 113 Black South African men. To further assess for potentially functional common and rare variant associations, here we interrogate 247,780 exomic variants for 798 Black South African men using a case versus control or aggressive versus non-aggressive study design. Notable genes of interest include HCP5, RFX6 and H3C1 for risk, and MKI67 and KLF5 for aggressive disease. Our study highlights the need for further inclusion across the African diaspora to establish African-relevant risk models aimed at reducing prostate cancer health disparities. © 2023, The Author(s).
Authors & Co-Authors
Soh, Pamela X.Y.
Australia, Sydney
The University of Sydney
Petersen, Desiree C.
South Africa, Stellenbosch
Stellenbosch University
Gheybi, Kazzem
Australia, Sydney
The University of Sydney
van Zyl, Smit
South Africa, Sovenga
University of Limpopo
Jiang, Jue
Australia, Sydney
The University of Sydney
Patrick, Sean Mark
South Africa, Pretoria
University of Pretoria
Campbell, Raymond
Unknown Affiliation
Mutambirwa, Shingai Bertrand Angelo
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
Bornman, M. S.Riana
South Africa, Pretoria
University of Pretoria
Hayes, Vanessa M.
Australia, Sydney
The University of Sydney
South Africa, Pretoria
University of Pretoria
South Africa, Sovenga
University of Limpopo
Statistics
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1038/s41467-023-43726-w
ISSN:
20411723
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Male