Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro
Cell Reports, Volume 39, No. 5, Article 110772, Year 2022
Notification
URL copied to clipboard!
Description
Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infection and receive the most vaccines. Bacille Calmette-Guérin (BCG) protects infants against disseminated tuberculosis (TB) and TB-unrelated infections via incompletely understood mechanisms. We employ mass-spectrometry-based metabolomics of blood plasma to profile BCG-induced infant responses in Guinea-Bissau in vivo and the US in vitro. BCG-induced lysophosphatidylcholines (LPCs) correlate with both TLR-agonist- and purified protein derivative (PPD, mycobacterial antigen)-induced blood cytokine production in vitro, raising the possibility that LPCs contribute to BCG immunogenicity. Analysis of an independent newborn cohort from The Gambia demonstrates shared vaccine-induced metabolites, such as phospholipids and sphingolipids. BCG-induced changes to the plasma lipidome and LPCs may contribute to its immunogenicity and inform the development of early life vaccines. © 2022 The Authors
Authors & Co-Authors
Diray-Arce, Joann
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Angelidou, Asimenia
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Jensen, Kristoffer Jarlov
Denmark, Odense
Syddansk Universitet
Denmark, Lyngby
Technical University of Denmark
Conti, Maria Giulia
United States, Boston
Boston Children's Hospital
Italy, Rome
Sapienza Università Di Roma
Pettengill, Matthew Aaron
United States, Boston
Boston Children's Hospital
United States, Philadelphia
Thomas Jefferson University
Liu, Mark
United States, Boston
Boston Children's Hospital
Van Haren, Simon Daniël
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Idoko, Olubukola T.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Kollmann, Tobias R.
Australia, Perth
The University of Western Australia
Kampmann, Beate B.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Steen, Hanno
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
Ozonoff, Al
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
Benn, Christine Stabell
Denmark, Odense
Syddansk Universitet
Levy, Ofer
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
Statistics
Citations: 8
Authors: 14
Affiliations: 11
Identifiers
Doi:
10.1016/j.celrep.2022.110772
ISSN:
22111247
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Gambia
Guinea
Guinea-Bissau