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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Performance of rest myocardial perfusion imaging in the management of acute chest pain in the emergency room in developing nations (PREMIER trial)
Journal of Nuclear Cardiology, Volume 19, No. 6, Year 2012
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Description
Background: Rest myocardial perfusion imaging (MPI) is effective in managing patients with acute chest pain in developed countries. We aimed to define the role and feasibility of rest MPI in low-to-middle income countries. Methods and Results: Low-to-intermediate risk patients (n = 356) presenting with chest pain to ten centers in eight developing countries were injected with a Tc-99m-based tracer, and standard imaging was performed. The primary outcome was a composite of death, non-fatal myocardial infarction (MI), recurrent angina, and coronary revascularization at 30 days. Sixty-nine patients had a positive MPI (19.4%), and 52 patients (14.6%) had a primary outcome event. An abnormal rest-MPI result was the only variable which independently predicted the primary outcome [adjusted odds ratio (OR) 8.19, 95% confidence interval 4.10-16.40, P =.0001]. The association of MPI result and the primary outcome was stronger (adjusted OR 17.35) when only the patients injected during pain were considered. Rest-MPI had a negative predictive value of 92.7% for the primary outcome, improving to 99.3% for the hard event composite of death or MI. Conclusions: Our study demonstrates that rest-MPI is a reliable test for ruling out MI when applied to patients in developing countries. © 2012 American Society of Nuclear Cardiology.
Authors & Co-Authors
Better, Nathan
Australia, Melbourne
Royal Melbourne Hospital
Karthikeyan, Ganesan
India, New Delhi
All India Institute of Medical Sciences, new Delhi
Vítola, João Vicente
Brazil, Curitiba
Quanta Diagnóstico e Terapia
Fatima, Arzoo
Pakistan, Lahore
Institute of Nuclear Medicine and Oncology
Peix, Amalia T.
Cuba, Havana
Institute of Cardiology
Novak, Maja Dolenc
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Soares, Jose
Brazil, Sao Paulo
Universidade de São Paulo
Bien, Vu Dien
Viet Nam, Hanoi
Central Hospital Tran Hung Dao
Briones, Pilar Orellana
Chile, Santiago
Pontificia Universidad Católica de Chile
Vangu, Mboyo Di Tamba Heben Willy
South Africa, Johannesburg
University of the Witwatersrand
Soni, Nischal
South Africa, Pretoria
University of Pretoria
Nguyen, Anna
Australia, Melbourne
Royal Melbourne Hospital
Dondi, Maurizio
Austria, Vienna
International Atomic Energy Agency, Vienna
Statistics
Citations: 22
Authors: 13
Affiliations: 12
Identifiers
Doi:
10.1007/s12350-012-9622-x
ISSN:
10713581
e-ISSN:
15326551
Research Areas
Cancer
Study Design
Case-Control Study