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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Trends among platelet function, arterial calcium, and vascular function measures
Platelets, Volume 34, No. 1, Article 2238835, Year 2023
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Description
Arterial tonometry and vascular calcification measures are useful in cardiovascular disease (CVD) risk assessment. Prior studies found associations between tonometry measures, arterial calcium, and CVD risk. Activated platelets release angiopoietin-1 and other factors, which may connect vascular structure and platelet function. We analyzed arterial tonometry, platelet function, aortic, thoracic and coronary calcium, and thoracic and abdominal aorta diameters measured in the Framingham Heart Study Gen3/NOS/OMNI-2 cohorts (n = 3,429, 53.7% women, mean age 54.4 years ±9.3). Platelet reactivity in whole blood or platelet-rich plasma was assessed using 5 assays and 7 agonists. We analyzed linear mixed effects models with platelet reactivity phenotypes as outcomes, adjusting for CVD risk factors and family structure. Higher arterial calcium trended with higher platelet reactivity, whereas larger aortic diameters trended with lower platelet reactivity. Characteristic impedance (Zc) and central pulse pressure positively trended with various platelet traits, while pulse wave velocity and Zc negatively trended with collagen, ADP, and epinephrine traits. All results did not pass a stringent multiple test correction threshold (p < 2.22e-04). The diameter trends were consistent with lower shear environments invoking less platelet reactivity. The vessel calcium trends were consistent with subclinical atherosclerosis and platelet activation being inter-related. © This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
Authors & Co-Authors
Chan, Melissa Victoria
United States, Boston
Boston University
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Nkambule, Bongani Brian
United States, Boston
Boston University
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Thibord, Florian
United States, Boston
Boston University
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Lachapelle, Amber Rose
United States, Boston
Boston University
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Ramachandran, Vasan S.
United States, Boston
Boston University
United States, Boston
School of Public Health
United States, San Antonio
University of Texas Health Science Center at San Antonio
Benjamin, Emelia J.
United States, Boston
Boston University
United States, Boston
School of Public Health
Hamburg, Naomi M.
United States, Boston
Boston University
Chen, Minghuei
United States, Boston
Boston University
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Mitchell, Gary F.
United States, Norwood
Cardiovascular Engineering, Inc, Massachusetts
Johnson, Andrew Danner
United States, Boston
Boston University
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Statistics
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1080/09537104.2023.2238835
ISSN:
09537104
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Female