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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development
Journal of Infectious Diseases, Volume 210, No. 8, Year 2014
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Description
Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development. © The Author 2014.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6083926/bin/jiu260_supplementary_data.zip
Authors & Co-Authors
Sanderson-Smith, Martina L.
Australia, Wollongong
Illawarra Health and Medical Research Institute
Guglielmini, Julien
France, Paris
Institut Pasteur, Paris
France, Paris
Cnrs Centre National de la Recherche Scientifique
Henningham, Anna
Australia, Brisbane
Australian Infectious Diseases Research Centre
Steer, Andrew C.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Royal Children's Hospital, Melbourne
Dale, J. B.
United States, Memphis
University of Tennessee Health Science Center
Curtis, Nigel C.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Australia, Melbourne
University of Melbourne
Beall, Bernard W.
United States, Atlanta
Centers for Disease Control and Prevention
Walker, Mark J.
Australia, Brisbane
Australian Infectious Diseases Research Centre
Carapetis, Jonathan Rhys
Australia, Perth
The University of Western Australia
Smeesters, Pierre R.
Belgium, Brussels
Université Libre de Bruxelles
Australia, Melbourne
Murdoch Children's Research Institute
Batzloff, Michael R.
Australia, Wollongong
Illawarra Health and Medical Research Institute
Towers, Rebecca J.
Australia, Wollongong
Illawarra Health and Medical Research Institute
Goossens, Herman J.
Belgium, Brussels
Université Libre de Bruxelles
Malhotra-Kumar, Surbhi
Belgium, Brussels
Université Libre de Bruxelles
Torres, Rosângela Stadnick Lauth De Almeida
Unknown Affiliation
Low, Donald Edward
Unknown Affiliation
Mcgeer, Allison J.
Unknown Affiliation
Křížová, Pavla
Unknown Affiliation
el-Tayeb, Sawsan H.M.
Unknown Affiliation
Kado, Joseph H.
Unknown Affiliation
van der Linden, Mark P.G.
Unknown Affiliation
Erdem, Güliz
Unknown Affiliation
Watanabe, Haruo
Unknown Affiliation
Sow, Samba Ousmane
Unknown Affiliation
Tamboura, Boubou
Unknown Affiliation
Melo-Cristino, José Crossed D.Sign©
Unknown Affiliation
Engel, Mark E.
Unknown Affiliation
Mayosi, Bongani M.
Unknown Affiliation
Whitelaw, Andrew C.
Unknown Affiliation
Darenberg, Jessica
Unknown Affiliation
Henriques-Normark, Brigitta
Unknown Affiliation
Efstratiou, Androulla
Unknown Affiliation
Statistics
Citations: 226
Authors: 32
Affiliations: 15
Identifiers
Doi:
10.1093/infdis/jiu260
ISSN:
00221899
Research Areas
Noncommunicable Diseases