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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Exceptional genetic variability of hepatitis B virus indicates that Rwanda is east of an emerging African genotype E/A1 divide
Journal of Medical Virology, Volume 81, No. 3, Year 2009
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Description
In Western Africa, hepatitis B virus (HBV) genotype E predominates throughout a vast crescent spanning from Senegal to Namibia and at least to the Central African Republic to the East. Although from most of the eastern parts of sub-Saharan Africa only limited sets of strains have been characterized, these belong predominantly to genotype A. To study how far the genotype E crescent extends to the East, a larger number of HBV strains from Rwanda were analyzed. Phylogenetic analysis of 45 S fragment sequences revealed strains of genotypes A (n = 30), D (n = 10), C (n = 4), and B (n = 1). Twelve genotype A sequences formed a new cluster clearly separated from the reference strains of theknown sub-genotypes. Thus, with four genotypes and at least six sub-genotypes and a new cluster of genotype A strains, HBV shows an exceptional genetic variability in this small country, unprecedented in sub-Saharan Africa. Despite this exceptional genetic variability, not a single genotype E virus was found indicating that this country does not belong to the genotype E crescent, but is east of an emerging African genotype E/A1 divide. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Hübschen, Judith M.
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Mugabo, Jules Semahore
Rwanda, Kigali
Tracplus - Center for Infectious Disease Control
Peltier, Alexandra
Rwanda, Kigali
Esther Project/luxembourg Lux-development
Karasi, Jean Claude
Luxembourg, Luxembourg
Retrovirology Laboratory Luxembourg
Sausy, Aurélie
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Kirpach, P.
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Arendt, Vic
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Muller, Claude P.
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Statistics
Citations: 49
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1002/jmv.21412
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Central African Republic
Namibia
Rwanda
Senegal