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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rise in rifampicin-monoresistant tuberculosis in Western Cape, South Africa
International Journal of Tuberculosis and Lung Disease, Volume 16, No. 2, Year 2012
Notification
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Description
SETTING: Brewelskloof Hospital, Western Cape, South Africa. OBJECTIVES: To verify the perceived increase in rifampicin monoresistant tuberculosis (RMR-TB) in the Cape Winelands-Overberg region and to identify potential risk factors. DESIGN: A retrospective descriptive study of trends in RMR-TB over a 5-year period (2004-2008), followed by a case-control study of RMR and isoniazid (INH) monoresistant TB cases, diagnosed from April 2007 to March 2009, to assess for risk factors. RESULTS: The total number of RMR-TB cases more than tripled, from 31 in 2004 to 98 in 2008. The calculated doubling time was 1.63 years (95%CI 1.18-2.66). For the assessment of risk factors, 95 RMR-TB cases were objectively verified on genotypic and phenotypic analysis. Of 108 specimens genotypically identified as RMR cases, 13 (12%) were misidentified multidrugresistant TB. On multivariate analysis, previous use of antiretroviral therapy (OR 6.4, 95%CI 1.3-31.8), alcohol use (OR 4.8, 95%CI 2.0-11.3) and age ≥40 years (OR 5.8, 95%CI 2.4-13.6) were significantly associated with RMR-TB. CONCLUSION: RMR-TB is rapidly increasing in the study setting, particularly among patients with advanced human immunodeficiency virus (HIV) disease. Routine drug susceptibility testing should be considered in all TB-HIV co-infected patients, and absence of INH resistance should be confirmed phenotypically if genotypic RMR-TB is detected. © 2012 The Union.
Authors & Co-Authors
Mukinda, Fidele Kanyimbu
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Theron, D.
United Kingdom, Worcester
Brewelskloof Hospital
Van Der Spuy, Gian D.
South Africa, Tygerberg
South African Medical Research Council
Jacobson, Karen Rita
United States, Boston
Massachusetts General Hospital
Roscher, M.
United Kingdom, Worcester
Brewelskloof Hospital
Streicher, Elizabeth Maria
South Africa, Tygerberg
South African Medical Research Council
Musekiwa, Alfred
South Africa, Tygerberg
South African Medical Research Council
Coetzee, Gerrit J.
South Africa, Johannesburg
National Health Laboratory Service
Victor, Thomas Calldo
South Africa, Tygerberg
South African Medical Research Council
Marais, Ben J.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Nachega, J. B.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Warren, Robin Mark
South Africa, Tygerberg
South African Medical Research Council
Schaaf, Hendrik Simon
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Statistics
Citations: 73
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.5588/ijtld.11.0116
ISSN:
10273719
Research Areas
Health System And Policy
Infectious Diseases
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Locations
South Africa